Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes
| Autor: | Elena Larrieta-Carrasco, Paula Grandini-Rosales, Teresa Villarreal-Molina, Sofia Moran-Ramos, Stanley L. Hazen, Rogelio Hernández-Pando, Simon T. Hui, Francisco J. Gómez-Pérez, Paola León-Mimila, Luis Macías-Kauffer, Aldons J. Lusis, Marisol Olivares-Arevalo, Carlos A. Aguilar-Salinas, Israel González-González, Samuel Canizales-Quinteros, Francisco Campos-Pérez, Blanca E. López-Contreras, Diana M. Shih, Xinmin S. Li, Adriana Huertas-Vazquez, Zeneng Wang, Elvira Ocampo-Medina, Hugo Villamil-Ramírez |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Biopsy Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Trimethylamine N-oxide Type 2 diabetes 030204 cardiovascular system & hematology digestive system Article Choline Bile Acids and Salts Methylamines 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Betaine Insulin resistance Non-alcoholic Fatty Liver Disease Internal medicine Mexican Americans Internal Medicine medicine Humans Obesity Bile acid business.industry Fatty liver nutritional and metabolic diseases General Medicine Middle Aged medicine.disease digestive system diseases Diabetes Mellitus Type 2 Liver chemistry Female Insulin Resistance Steatohepatitis business Biomarkers |
| Zdroj: | Diabetes Metab |
| ISSN: | 1262-3636 |
| DOI: | 10.1016/j.diabet.2020.07.010 |
| Popis: | Aims Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). These associations could be mediated by insulin resistance. However, the relationships among these metabolites, insulin resistance and NAFLD have not been thoroughly investigated. Moreover, it has recently been suggested that TMAO could play a role in NAFLD by altering bile acid metabolism. We examined the association between circulating TMAO, choline and betaine levels and NAFLD in obese subjects. Methods Serum TMAO, choline, betaine and bile acid levels were measured in 357 Mexican obese patients with different grades of NAFLD as determined by liver histology. Associations of NAFLD with TMAO, choline and betaine levels were tested. Moreover, association of TMAO levels with non-alcoholic steatohepatitis (NASH) was tested separately in patients with and without T2D. Results TMAO and choline levels were significantly associated with NAFLD histologic features and NASH risk. While increased serum TMAO levels were significantly associated with NASH in patients with T2D, in non-T2D subjects this association lost significance after adjusting for sex, BMI and HOMA2-IR. Moreover, circulating secondary bile acids were associated both with increased TMAO levels and NASH. Conclusions In obese patients, circulating TMAO levels were associated with NASH mainly in the presence of T2D. Functional studies are required to evaluate the role of insulin resistance and T2D in this association, both highly prevalent in NASH patients. |
| Databáze: | OpenAIRE |
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