Natural course of myelodysplastic syndromes - Helsinki experience
| Autor: | R. Lintula, L. Teerenhovi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Adolescent Gastroenterology 03 medical and health sciences 0302 clinical medicine Bone Marrow hemic and lymphatic diseases Internal medicine Precursor cell medicine Humans Platelet Finland Short survival Aged Natural course Leukemia business.industry Myelodysplastic syndromes Age Factors Hematology Middle Aged Prognosis medicine.disease Peripheral blood 3. Good health medicine.anatomical_structure Myelodysplastic Syndromes 030220 oncology & carcinogenesis Acute Disease Bone marrow business Median survival 030215 immunology |
| Zdroj: | Scandinavian Journal of Haematology. 36:102-106 |
| ISSN: | 0036-553X |
| DOI: | 10.1111/j.1600-0609.1986.tb00853.x |
| Popis: | Between the years 1969 and 1984 162 new patients with myelodysplastic syndromes were diagnosed in the Helsinki University Central Hospital. The median survival was 29 months. The survival was best in the FAB-groups with 5 % bone marrow blasts, RAEB and RAEBt, the median survival was 21 and 13 months, respectively. In the CMML-group the survival was almost as short as that in the RAEBt-group, median 16 months. These differences in survival between the FAB-groups were highly significant (p = 0.003). Other variables that predicted short survival were Hb < 10 g/1, platelets < 150X 109/1, and the presence of peripheral blood blast cells. 26.5 % of all patients progressed to ANLL. The patients in the FAB-groups with > 5 % bone marrow blasts cells (RAEB, RAEBt) expired more often in ANLL when compared with patients with < 5 % bone marrow blast cells (RA, RARS) and with patients with CMML (p < 0.001). Other variables that predicted progression to ANLL were the presence of peripheral blood blast cells (p = 0.01) and the age < 65 years (p < 0.01). Besides ANLL, infection and/or bleeding were common causes of death. Two thirds of all deaths were due to these causes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|