Cyclopeptide mushroom poisoning: A retrospective series of 204 patients
| Autor: | Jérémy Lecot, Morgane Cellier, Arnaud Courtois, Dominique Vodovar, Gaël Le Roux, Anne Landreau, Magali Labadie, Chloé Bruneau, Alexis Descatha |
|---|---|
| Přispěvatelé: | Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), CHU Bordeaux [Bordeaux], Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques (ICAT), Université d'Angers (UA), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hofstra University [Hempstead] |
| Rok vydání: | 2023 |
| Předmět: |
mushroom poisoning
Pharmacology cyclopeptide mushroom [SDV]Life Sciences [q-bio] [SDV.TOX]Life Sciences [q-bio]/Toxicology severity factor [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology amatoxins acute liver failure General Medicine Amanita phalloides poisoning poison control centres Toxicology |
| Zdroj: | Basic and Clinical Pharmacology and Toxicology Basic and Clinical Pharmacology and Toxicology, 2023, 132 (6), pp.528-537. ⟨10.1111/bcpt.13858⟩ |
| ISSN: | 1742-7843 1742-7835 |
| Popis: | International audience; Cyclopeptide mushroom poisoning is responsible for 90%-95% of deaths from macrofungi ingestion. The main objectives of this study are to describe cases of cyclopeptide mushroom poisoning and to determine risk factors that may influence the severity/mortality of poisoned patients. We included all cases of amatoxin toxicity reported to two French Poison Centers from 2013 through 2019. We compared the severity with the Poison Severity Score (PSS) and the outcomes of patients using simple logistic regression and multinomial logistic regression. We included 204 cases of amatoxin toxicity. More than three-quarters developed an increase in AST and/or ALT (78.1%), and over half developed a decrease in prothrombin ratio ( |
| Databáze: | OpenAIRE |
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