Pulmonary artery endothelium-dependent vasodilation is impaired in a chicken model of pulmonary hypertension
| Autor: | Joan S. Jeffrey, Ted W. Odom, Elizabeth J. Becker, Luis A. Martinez-Lemus, R.Kelly Hester |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Nitroprusside medicine.medical_specialty animal structures Endothelium Physiology Hypertension Pulmonary Vasodilator Agents Vasodilation Pulmonary Artery Arginine Nitric oxide chemistry.chemical_compound Physiology (medical) medicine.artery Internal medicine Papaverine medicine Animals Enzyme Inhibitors Calcimycin Lung Ionophores business.industry Respiratory disease medicine.disease Pulmonary hypertension Acetylcholine Surgery Disease Models Animal medicine.anatomical_structure NG-Nitroarginine Methyl Ester chemistry Pulmonary artery Cardiology Sodium nitroprusside Endothelium Vascular business Chickens medicine.drug |
| Zdroj: | The American journal of physiology. 277(1) |
| ISSN: | 0002-9513 |
| Popis: | Among chicken strains, broilers are prone to pulmonary hypertension, whereas Leghorns are not. Relaxations to endothelium-dependent (ACh, A23187) and endothelium-independent [sodium nitroprusside (SNP), papaverine (PPV)] vasodilators were compared in preconstricted pulmonary artery (PA) rings from these chicken strains. ACh (10−7, 10−6, and 10−5 M)- and A23187 (10−6 and 10−5.5 M)-induced relaxations were smaller ( P < 0.05) in broilers than Leghorns. N G-nitro-l-arginine methyl ester (10−3.5 M) caused similar reductions in ACh-induced relaxations in both strains.l-Arginine (10−4 M) enhanced ACh-induced relaxations more in broilers than Leghorns. Relaxations to 10−10–10−6M SNP did not differ between strains, but were greater ( P < 0.05) in broilers than Leghorns at higher concentrations (10−5 and 10−4 M). PPV (10−4 M)- and SNP (10−4 M)-induced maximal relaxations were greater in broilers than in Leghorns (176.2 ± 14.7 vs. 120.9 ± 14.7% and 201.3 ± 7.8 vs. 171.2 ± 10.7%, respectively, P < 0.05). Broiler PA rings appear to have increased intrinsic tone and reduced endothelium-derived nitric oxide activity, both of which may contribute to the susceptibility of broiler chickens to pulmonary hypertension. |
| Databáze: | OpenAIRE |
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