Vitamin B12 and folate depletion: clinical evidence in a neurological population
| Autor: | Pier Luigi Scapicchio, Tatiana Cattaruzza, Rita Moretti, Paola Torre, Giuseppe Cazzato, Rodolfo M. Antonello |
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| Rok vydání: | 2004 |
| Předmět: |
Vitamin
Adult Male Pediatrics medicine.medical_specialty Population Statistics as Topic chemistry.chemical_compound Folic Acid Risk Factors Cognitive development medicine Dementia Humans Vitamin B12 education Aged Retrospective Studies Aged 80 and over education.field_of_study business.industry Cognition Vitamin B 12 Deficiency General Medicine Middle Aged medicine.disease chemistry Clinical evidence Cohort Hematinics Female Neurology (clinical) business Cognition Disorders |
| Zdroj: | The neurologist. 10(6) |
| ISSN: | 1074-7931 |
| Popis: | In cross-sectional studies, low levels of folate and vitamin B12 have been associated with poor cognition and dementia. Results are quite controversial and a debate continues in the literature. Still not completely understood are the differential roles of folate and vitamin B12 in memory acquisition and cognitive development. More intriguing and not fully understood is the rule that treating a vitamin B12-deficient patient with folate may exacerbate the neurological consequences of either deficiency. Starting from these quite confusing perspectives, the aim of this study was to define a possible role of vitamin B12 and folate in cognitive disruption. Data were collected among a cohort of people, admitted to the Neurology Clinic of the University of Trieste, in a period between November 1,2000, and November 1, 2002. We examine potential risk factors, concomitant drug-therapies, and cognitive global performance and correlate these parameters with folate and vitamin B 12 serum levels.We discuss the results with an overview of the literature. |
| Databáze: | OpenAIRE |
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