Association between plasma concentrations of vitamin D metabolites and depressive symptoms throughout pregnancy in a prospective cohort of Brazilian women
| Autor: | Janet Trujillo, Amanda C. Cunha Figueiredo, Ana Amélia Freitas-Vilela, Maria Beatriz Trindade de Castro, Amanda Farnum, Ana Beatriz Franco-Sena, Michael F. Holick, Rana Mokhtar, Fernanda Rebelo, Geraldo Marcelo da Cunha, Gilberto Kac |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Logistic regression Young Adult 03 medical and health sciences 0302 clinical medicine Calcitriol Pregnancy medicine Vitamin D and neurology Humans Endocrine system Prospective Studies 030212 general & internal medicine Vitamin D Prospective cohort study Biological Psychiatry Depressive symptoms Depression (differential diagnoses) Gynecology Depression Obstetrics business.industry Micronutrient medicine.disease 030227 psychiatry Pregnancy Complications Psychiatry and Mental health Female business Brazil |
| Zdroj: | Journal of Psychiatric Research. 95:1-8 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2017.07.009 |
| Popis: | Plasma concentrations of vitamin D metabolites can be inversely associated with depressive symptoms. However, few longitudinal studies have investigated this association, especially during pregnancy. The aim of this study was to investigate the association between concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxivitamin D [1,25(OH) 2 D] with the occurrence of depressive symptoms throughout pregnancy. A prospective cohort of 179 women was followed at 5th-13th, 20th-26th and 30th-36th gestational weeks. At each trimester of pregnancy, the plasma concentrations of 25(OH)D and 1,25(OH) 2 D were analyzed by liquid chromatography tandem mass spectroscopy. Vitamin D status was categorized according to the Endocrine Society Practice Guidelines and the Institute of Medicine. Depressive symptoms were measured at each trimester using the Edinburgh Postnatal Depressive Scale (cutoff ≥13). Statistical analyses included random intercept logistic regression models for longitudinal analyses. In the first trimester, the prevalence of 25(OH)D |
| Databáze: | OpenAIRE |
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