Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure
| Autor: | K. C. Lee, RuRu Chun-Ju Chiang, Johan van Soest, Melinda Schuurman, Wen-Chung Lee, Xander A. A. M. Verbeek, Melle Sieswerda, Gijs Geleijnse, Andre Dekker |
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| Přispěvatelé: | RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Radiotherapie |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty EUROPE Science MEDLINE Taiwan IMPROVEMENT Information technology Oral cavity Article 03 medical and health sciences 0302 clinical medicine Cancer epidemiology Adjuvant therapy Medicine Humans 030212 general & internal medicine HEAD Stage (cooking) Aged Netherlands Proportional Hazards Models OUTCOMES Multidisciplinary business.industry Incidence (epidemiology) Cancer Middle Aged CARE medicine.disease Prognosis Survival Analysis TRENDS Cancer registry Privacy preserving Privacy 030220 oncology & carcinogenesis Emergency medicine Multivariate Analysis Regression Analysis Female Mouth Neoplasms business Software |
| Zdroj: | Scientific Reports, 10(1):20526. Nature Publishing Group Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The difference in incidence of oral cavity cancer (OCC) between Taiwan and the Netherlands is striking. Different risk factors and treatment expertise may result in survival differences between the two countries. However due to regulatory restrictions, patient-level analyses of combined data from the Netherlands and Taiwan are infeasible. We implemented a software infrastructure for federated analyses on data from multiple organisations. We included 41,633 patients with single-tumour OCC between 2004 and 2016, undergoing surgery, from the Taiwan Cancer Registry and Netherlands Cancer Registry. Federated Cox Proportional Hazard was used to analyse associations between patient and tumour characteristics, country, treatment and hospital volume with survival. Five factors showed differential effects on survival of OCC patients in the Netherlands and Taiwan: age at diagnosis, stage, grade, treatment and hospital volume. The risk of death for OCC patients younger than 60 years, with advanced stage, higher grade or receiving adjuvant therapy after surgery was lower in the Netherlands than in Taiwan; but patients older than 70 years, with early stage, lower grade and receiving surgery alone in the Netherlands were at higher risk of death than those in Taiwan. The mortality risk of OCC in Taiwanese patients treated in hospitals with higher hospital volume (≥ 50 surgeries per year) was lower than in Dutch patients. We conducted analyses without exchanging patient-level information, overcoming barriers for sharing privacy sensitive information. The outcomes of patients treated in the Netherlands and Taiwan were slightly different after controlling for other prognostic factors. |
| Databáze: | OpenAIRE |
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