In vivo anti-malarial effect of the beta-amino alcohol 1t on Plasmodium berghei
| Autor: | Aélig Robin, Peter G. Kremsner, Sabine L. Flitsch, Jana Held, Noemi Bahamontes-Rosa, J. F. J. Kun, K. Bucher, Wolfgang Hoffmann |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Plasmodium berghei Pharmacology Parasitemia Apicomplexa Antimalarials Inhibitory Concentration 50 Mice In vivo parasitic diseases Parasite hosting Animals Mice Inbred BALB C General Veterinary biology Plasmodium falciparum General Medicine biology.organism_classification Virology Amino Alcohols Survival Analysis In vitro Malaria Infectious Diseases Parasitology Insect Science Protozoa Female Injections Intraperitoneal |
| Zdroj: | Parasitology research. 104(6) |
| ISSN: | 1432-1955 |
| Popis: | Glycerol derivatives are a class of compounds, which are easy and inexpensive to produce with potent anti-malarial activities against blood stages of Plasmodium falciparum in vitro. In the present study, one of these compounds, termed 1t, which had the lowest IC(50) values, was assessed in a murine malarial model. Nuclear magnetic resonance imaging and Balb/c mice infected with Plasmodium berghei ANKA strain were treated in a 4-day suppressive test. Mice received a once-daily intraperitoneal administration of 50 mg/Kg of the drug for 4 days. Although no parasitaemia clearance was reached, a slower parasite proliferation and a slightly longer survival time compared with the placebo group were observed. |
| Databáze: | OpenAIRE |
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