Affinity of Tomopenem (CS-023) for Penicillin-Binding Proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa▿
| Autor: | Tetsufumi Koga, Nobuhisa Masuda, Eiko Namba, Chika Sugihara, Masayo Kakuta, Takashi Fukuoka |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Imipenem
Staphylococcus aureus Penicillin binding proteins Microbial Sensitivity Tests medicine.disease_cause Microbiology Tomopenem chemistry.chemical_compound medicine polycyclic compounds Escherichia coli Penicillin-Binding Proteins Pharmacology (medical) Mechanisms of Action: Physiological Effects Pharmacology biology Pseudomonas aeruginosa biochemical phenomena metabolism and nutrition biology.organism_classification Enterobacteriaceae Infectious Diseases chemistry Carbapenems Mutation bacteria Pseudomonadaceae medicine.drug |
| Popis: | Tomopenem (formerly CS-023), a novel 1β-methylcarbapenem, exhibited high affinity for penicillin-binding protein (PBP) 2 in Staphylococcus aureus , PBP 2 in Escherichia coli , and PBPs 2 and 3 in Pseudomonas aeruginosa , which are considered major lethal targets. Morphologically, tomopenem induced spherical forms in E. coli and short filamentation with bulges in P. aeruginosa , which correlated with the drug's PBP profiles. The potential of resistance of these bacteria to tomopenem was comparable to that to imipenem. |
| Databáze: | OpenAIRE |
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