SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus
| Autor: | Tim J. Craig, Andrzej Wolski, Peter Weightman, Andrea Varro, James Ingham, Caroline I. Smith, Andrew D. Smith, Subhasis Chattopadhyay, M. Surman, P Harrison, Michele R.F. Siggel-King, D. Mark Pritchard, Antonio Cricenti, G. M. Holder, David Martin, Steve Barrett, Marco Luce |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty Materials science adenocarcinoma scanning near-field optical microscopy Crypt tissue 02 engineering and technology DNA 021001 nanoscience & nanotechnology Condensed Matter Physics medicine.disease Electronic Optical and Magnetic Materials 03 medical and health sciences 0302 clinical medicine Feature (computer vision) 030220 oncology & carcinogenesis Barrett's oesophagus medicine Adenocarcinoma infrared radiation 0210 nano-technology |
| Zdroj: | Physica status solidi. B, Basic research 255 (2018). doi:10.1002/pssb.201700518 info:cnr-pdr/source/autori:Craig, Timothy; Smith, Andrew D.; Holder, Gareth M.; Ingham, James; Smith, Caroline I.; Varro, Andrea; Pritchard, D. Mark; Barrett, Steve D.; Martin, David S.; Harrison, Paul; Wolski, Andrzej; Cricenti, Antonio; Luce, Marco; Surman, Mark; Chattopadhyay, Swapan; Weightman, Peter; Siggel-King, Michele R. F./titolo:SNOM Imaging of a Crypt-Like Feature in Adenocarcinoma Associated with Barrett's Oesophagus/doi:10.1002%2Fpssb.201700518/rivista:Physica status solidi. B, Basic research/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:255 PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS |
| DOI: | 10.1002/pssb.201700518 |
| Popis: | The development of more accurate and sensitive diagnostic techniques is a key factor in efforts to improve cancer survival rates. The technique of infrared aperture fibre scanning near-field optical microscopy (IR-SNOM), together with radiation from the infrared free-electron laser (IR-FEL) on ALICE at Daresbury Laboratory (UK), has been used to obtain IR images of a crypt-like feature and the surrounding tissue; the tissue was taken from a patient with oesophageal adenocarcinoma and with a history of Barrett's oesophagus. We have shown that the DNA signal is enhanced relative to other contributions in the region of the crypt, and the glycoprotein signal shows a less pronounced increase in the region of the crypt. The Amide II signal is found to be anti-correlated with the DNA and glycoprotein profiles. The absorbance of the Amide II signal is found to differ for three different types of cancer tissue. High-resolution IR images of the crypt reveal additional structure that would not be resolved in diffraction-limited techniques. |
| Databáze: | OpenAIRE |
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