High EREG Expression Is Predictive of Better Outcomes in Rectal Cancer Patients Receiving Neoadjuvant Concurrent Chemoradiotherapy
| Autor: | Yu-Feng Tian, Pei-Ling Hsieh, Ching-Chieh Yang, Chia-Lin Chou, Yow-Ling Shiue, Sung-Wei Lee, Wan-Shan Li, Cheng-Yi Lin |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Colorectal cancer Disease-Free Survival Epiregulin Young Adult 03 medical and health sciences Tumor Status 0302 clinical medicine Internal medicine Biopsy Biomarkers Tumor medicine Humans 030212 general & internal medicine Survival analysis Aged Aged 80 and over Tumor Regression Grade Predictive marker medicine.diagnostic_test Rectal Neoplasms business.industry Hazard ratio Chemoradiotherapy General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry Neoadjuvant Therapy 030220 oncology & carcinogenesis Female Transcriptome business |
| Zdroj: | Oncology. 98:549-557 |
| ISSN: | 1423-0232 0030-2414 |
| Popis: | Background/Aim: A great proportion of patients with rectal cancer initially present with locally advanced disease and can potentially benefit from neoadjuvant concurrent chemoradiotherapy (CCRT) for downstaging before surgery. However, risk and clinical outcome stratification remain a great challenge. We aimed to find the potential biomarker to predict the effect of neoadjuvant CCRT on rectal cancer. Methods: We identified epiregulin (EREG) as the most significant predictive marker for neoadjuvant CCRT response from the published rectal cancer transcriptome data set GSE35452. We collected 172 biopsy specimens from rectal cancer patients who received neoadjuvant CCRT followed by radical proctectomy, performed EREG immunohistochemistry, and analyzed the H-scores. We further examined the correlations between the expression level of EREG and clinicopathological features, tumor regression grade, and survival, including disease-specific survival (DSS), locoregional recurrence-free survival (LRFS), and metastasis-free survival (MeFS). Results: High EREG expression was significantly related to early pretreatment (pre-Tx) and posttreatment (post-Tx) tumor status (T1, T2, p = 0.047 and p < 0.001), pre-Tx and post-Tx negative nodal status (N0, p < 0.001 and p = 0.004), less vascular and perineurial invasion (p = 0.015 and p = 0.023), and higher tumor regression grade (p < 0.001). In the survival analysis, high EREG expression was significantly associated with better DSS (p < 0.0001), LRFS (p = 0.0004), and MeFS (p < 0.0001). In the multivariate analysis, high EREG expression remained prognostically significant for better DSS (p = 0.003; hazard ratio: 5.599). Conclusion: These data suggest that EREG is a potential predictive marker and therapeutic target in rectal cancer patients receiving neoadjuvant CCRT. |
| Databáze: | OpenAIRE |
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