Precision medicine of frontotemporal dementia from genotype to phenotype
| Autor: | Ru-Jing Ren, Ying Gao, Gang Wang, Ning Song, Xiang-Qian Che |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Genotype
Neuroimaging Neuroimaging biomarkers Bioinformatics 03 medical and health sciences 0302 clinical medicine mental disorders medicine Humans Dementia Genetic Predisposition to Disease 030212 general & internal medicine Precision Medicine Genetic Association Studies business.industry nutritional and metabolic diseases medicine.disease Precision medicine Phenotype nervous system diseases Frontotemporal Dementia Mutation Cohort Genotype to phenotype business 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | Frontiers in Bioscience. 23:1144-1165 |
| ISSN: | 1093-4715 1093-9946 |
| DOI: | 10.2741/4637 |
| Popis: | Frontotemporal dementia (FTD) is the second most common neurodegenerative cause of early-onset dementia. FTD has an important genetic component contributing to its pathogenic mechanisms. Currently, extensive research on neuroimaging biomarkers and neurochemical biomarkers in FTD is being conducted to address the clinical need for a sensitive and specific diagnostic marker. Here, we review the advances in genetics, biomarkers and treatment of FTD and how this may represent a shift towards precision medicine. To advance the clinical use of precision medicine, big data cohort for genotype/phenotype research and multidisciplinary team approaches are necessary. |
| Databáze: | OpenAIRE |
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