Structure-function correlations in erythropoietin formation and oxygen sensing in the kidney
| Autor: | Brigitte Kaissling, Armin Kurtz, M. Le Hir, Stephen T. Koury, Kai-Uwe Eckardt |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Endothelium Endothelium Vascular/physiopathology 610 Medizin chemistry.chemical_element Kidney Tubules Proximal/physiopathology In situ hybridization Biology Kidney Oxygen Kidney Tubules Proximal Oxygen/blood Erythropoietin/biosynthesis Internal medicine hemic and lymphatic diseases Drug Discovery medicine 570 Biowissenschaften Biologie Animals Humans Hypoxia Erythropoietin Genetics (clinical) ddc:610 Messenger RNA Anemia/pathology Anemia General Medicine Hypoxia (medical) Molecular medicine Cell biology Endocrinology medicine.anatomical_structure chemistry Molecular Medicine ddc:570 Endothelium Vascular medicine.symptom Anoxia/pathology Kidney/physiopathology medicine.drug |
| Zdroj: | Klinische Wochenschrift. 69(13) |
| ISSN: | 0023-2173 |
| Popis: | The kidney is the main site of erythropoietin (EPO) formation. Oxygen sensing in the kidney itself plays a major role in the control of EPO synthesis. By in situ hybridization it has been established that the EPO-producing cells are situated in the interstitium of the cortical labyrinth, but they have not been precisely identified. Morphological findings provide new insights into the location and mechanism of oxygen sensing in the kidney. In addition to causing an increase in the number of cells containing EPO messenger RNA, anemia provokes structural changes exclusively in the cortical labyrinth. Specifically, the fibroblasts become enlarged and show increased activity of 5'-nucleotidase, and the S1 segment of the proximal tubule shows similar alterations as in various models of hypoxia. Thus, structures that are situated in the close vicinity of the EPO-producing cells appear to be sensitive to decreased oxygen delivery. |
| Databáze: | OpenAIRE |
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