Genetic variability of purine nucleoside phosphorylase activity in the mouse: Relationship to Np-1 and Np-2
| Autor: | Floyd F. Snyder, Fred G. Biddle, Marcia J. Sparling, Trevor Lukey |
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| Rok vydání: | 1983 |
| Předmět: |
Erythrocytes
Hot Temperature Purine nucleoside phosphorylase Mice Inbred Strains Locus (genetics) Biology Biochemistry Mice Inbred strain Genetics Animals Pentosyltransferases Genetic variability Molecular Biology Gene Ecology Evolution Behavior and Systematics chemistry.chemical_classification Genetic Variation General Medicine Hydrogen-Ion Concentration Molecular biology Kinetics Purine-nucleoside phosphorylase activity Enzyme Genes Purine-Nucleoside Phosphorylase chemistry Specific activity |
| Zdroj: | Biochemical Genetics. 21:323-332 |
| ISSN: | 1573-4927 0006-2928 |
| DOI: | 10.1007/bf00499142 |
| Popis: | A survey of 37 inbred strains for erythrocyte purine nucleoside phosphorylase activity showed a greater than threefold range. Six of these strains had significantly greater activity than the others, and all of the high-activity strains had the Np-2 electrophoretic band. The high-purine nucleoside phosphorylase activity trait corresponding to Np-2 was inherited in an autosomal codominant manner and minor differences were apparent in thermal and kinetic properties between low- and high-activity strains. This work provides further support for there being either two structural loci for purine nucleoside phosphorylase, Np-1 and Np-2, or a regulatory-modifier locus. |
| Databáze: | OpenAIRE |
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