Free radical scavenging drugs, assessed by ESR studies: influence of hemoglobin
| Autor: | Guido Zimmer, Sigrid Pilz, Hans-Joachim Freisleben, Bernd Lammel, Eckard Schraven |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
chemistry.chemical_classification
Protein Synthesis Inhibitors Thiol Reagents Molsidomine Free Radicals Radical Electron Spin Resonance Spectroscopy Tiopronin Glutathione Hypoxia (medical) Biochemistry Cyclic N-Oxides chemistry.chemical_compound Hemoglobins chemistry Thiol medicine Spin Labels Hemoglobin medicine.symptom Scavenging Nuclear chemistry |
| Zdroj: | Free radical research communications. 3(6) |
| ISSN: | 8755-0199 |
| Popis: | To monitor free radical scavenging properties of drugs, the 'stable' radical 2,2,6,6-tetramethylpiperidino-1-oxyl (TEMPO) was used. The sydnonimine molsidomine (SIN-1) effectively reduced the ESR signal whereas the nitrate isosorbidemononitrate (ISMN) did not. Thiol reagents like 2-mercaptopropionylglycine (MPG) or glutathione (GSH) only were effective in the presence of Fe2+ or Fe3+. Protein-bound iron in hemoglobin proved about four times more effective in reducing ESR signal height by thiols. It is suggested that the decrease in thiol content adds to the lack in protein bound iron of hemoglobin to induce the burst of free radicals in hypoxia (ischemia) and reperfusion. |
| Databáze: | OpenAIRE |
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