Association between human parvovirus B19 and arthropathy in Belém, Pará, North Brazil
| Autor: | Talita Antônia Furtado Monteiro, Manoel Gomes da Silva Filho, Alexandre da Costa Linhares, Ronaldo Barros de Freitas |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Enzyme-Linked Immunosorbent Assay Human parvovirus Antibodies Viral Gastroenterology Polymerase Chain Reaction Sensitivity and Specificity law.invention Parvoviridae Infections law Internal medicine Arthropathy Parvovirus B19 Human Medicine Humans Child Polymerase chain reaction biology business.industry Parvovirus General Medicine biology.organism_classification medicine.disease Infectious Diseases medicine.anatomical_structure Immunoglobulin M Immunoglobulin G DNA Viral biology.protein Female Antibody Ankle Joint Diseases business Acute arthropathy Nested polymerase chain reaction Brazil |
| Zdroj: | Revista do Instituto de Medicina Tropical de Sao Paulo. 44(1) |
| ISSN: | 0036-4665 |
| Popis: | A total of 220 patients with arthropathy were selected in Belém, Pará between January 1994 and December 2000, and screened for the presence of human parvovirus B19 IgM and IgG antibodies by enzyme-linked immunosorbent assay (ELISA). A subgroup (n = 132) of patients with high levels of antibodies (either IgM+/IgG+ or IgM-/IgG+) were examined for the presence of DNA by polymerase chain reaction/nested PCR. Recent/active infection (detection of IgM and/or IgG-specific antibodies and presence of viral DNA) was identified in 47.7% of the 132 individuals with arthropathy. In our study, women were significantly more affected (59.7%) than men (35.4%) (P = 0.0006). The age group of 11-20 years (84.6%), among female patients, and 21-30 years (42.1%), among male, were those with the highest incidence rates. The analysis of the temporal distribution of B19-associated arthropaties showed a cyclic pattern, with peak incidence rates occuring at 3-5 year intervals. Significant diference (P = 0.01) was observed when comparing both the highest (39.0%) and the lowest (11.0%) seropositivity rates for the years of 1995 and 2000, respectively. The interfalangial joints of hands and feet were mostly affected, with 50.0% and 48.0% of cases among both women and men, respectively. In a smaller proportion, other joints such as those of knee, ankle, pulse and shoulder were affected. As for the duration, symptoms lasted 1 to 5 days in 54.0% of the individuals, whereas in 46.0% of them the disease lasted 6-10 days, if considered the subgroup (n = 63) of patients with recent/active infection by parvovirus B19. In our study, joint clinical manifestations occurred symmetrically. Our results indicate that B19 may be an important agent of arthropathies in our region, and this underscores the need for specific laboratory diagnosis when treating patients suffering from acute arthropathy, mainly pregnant women. |
| Databáze: | OpenAIRE |
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