Impact on rats from acute intratracheal inhalation exposures to WTC dusts

Autor:	Judith T. Zelikoff, Colette Prophete, Hyun-Wook Lee, Lung Chi Chen, Mitchell D. Cohen, Lori Horton, Maureen Sisco, Sung-Hyun Park
Rok vydání:	2020
Předmět:	Male Galectin 3 Health Toxicology and Mutagenesis Lymphocyte Receptor for Advanced Glycation End Products Physiology Spleen 010501 environmental sciences Toxicology 01 natural sciences Leukocyte Count 03 medical and health sciences 0302 clinical medicine Rats Inbred SHR White blood cell Administration Inhalation Animals Medicine Chemokine CCL5 Chemokine CCL2 0105 earth and related environmental sciences Air Pollutants Kidney Lung Inhalation business.industry Incidence (epidemiology) World trade center Dust Blood Proteins medicine.anatomical_structure Matrix Metalloproteinase 9 030228 respiratory system September 11 Terrorist Attacks business
Zdroj:	Inhalation Toxicology. 32:218-230
ISSN:	1091-7691 0895-8378
Popis:	Background: Studies have revealed the increased incidence of health disorders in First Responders (FR) who were at Ground Zero over the initial 72 hr after the World Trade Center (WTC) collapses. Previous studies in rats exposed to WTC dusts using exposure scenarios that mimicked FR mouthbreathing showed exposure led to altered expression of genes whose products could be involved in lung ailments. Nevertheless, it was uncertain if repeated exposures (as occurred in earliest days post-disaster) might have given rise to long-term changes in the lungs/other organs, in white blood cell (WBC) profiles, and/or systemic expression of select (mostly immune-related) proteins.Methods: To examine this, rats were exposed on 2 consecutive days (2 hr/d, intratracheal inhalation) to WTC dusts and then examined over a 1-yr period thereafter. At select times post-exposure, organ (lung, heart, liver, kidney, spleen) weights, WBC profiles, and blood levels of a variety of proteins were evaluated.Results: The study showed that over the 1-yr period, there were nominal effects on organ weights (absolute, index) as a result of the dust exposures. There were significant changes (relative to in naive rats) in WBC profiles, with exposed rats having increased monocyte-macrophage and decreased lymphocyte percentages. The study also found that dust exposure led to significant systemic increases in many proteins, including MCP-1, RANTES, MMP-9, RAGE, and Galectin-3.Conclusions: These results provide further support for our longstanding hypothesis that the WTC dusts could potentially have acted as direct inducers of many of the health effects that have been seen in the exposed FR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469190ef08cc8a85c99547f371555839 https://doi.org/10.1080/08958378.2020.1768322 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.