Modeling the Behavior of Red Blood Cells within the Caudal Vein Plexus of Zebrafish
| Autor: | Tijana R Djukic, Swapna Karthik, Igor Saveljic, Valentin Djonov, Nenad Filipovic |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Physiology deformable objects 610 Medicine & health 01 natural sciences lcsh:Physiology 010305 fluids & plasmas 03 medical and health sciences comparison with experimental data Caudal Vein Physiology (medical) 0103 physical sciences Blood plasma blood flow zebrafish embryo Zebrafish Original Research Plexus solid-fluid interation lcsh:QP1-981 biology Dynamics (mechanics) Biomechanics mathematical modeling Anatomy Blood flow biology.organism_classification 030104 developmental biology Zebrafish embryo Biophysics 570 Life sciences caudal vein plexus |
| Zdroj: | Frontiers in Physiology, Vol 7 (2016) Frontiers in Physiology Djukic, Tijana R; Karthik, Swapna; Saveljic, Igor; Djonov, Valentin; Filipovic, Nenad (2016). Modeling the Behavior of Red Blood Cells within the Caudal Vein Plexus of Zebrafish. Frontiers in physiology, 7(455), p. 455. Frontiers Research Foundation 10.3389/fphys.2016.00455 |
| ISSN: | 1664-042X |
| DOI: | 10.3389/fphys.2016.00455 |
| Popis: | Due to the important biological role of red blood cells (RBCs) in vertebrates, the analysis of reshaping and dynamics of RBCs motion is a critical issue in physiology and biomechanics. In this paper the behavior of RBCs within the immature capillary plexus during embryonic development of zebrafish has been analyzed. Relying on the fact that zebrafish embryos are small and optically transparent, it is possible to image the blood flow.. In this way the anatomy of blood vessels is monitored along with the circulation throughout their development. Numerical simulations were performed using a specific numerical model that combines fluid flow simulation, modeling of interaction of individual red blood cells immersed in blood plasma with the surrounding fluid and modeling the deformation of individual cells. The results of numerical simulations are in accordance with the in vivo observed region of interest within the caudal vein plexus of the zebrafish embryo. Good agreement of results demonstrates the capabilities of the developed numerical model to predict and analyze the motion and deformation of RBCs in complex geometries. The proposed model (methodology) will help to elucidate different rheological and hematological related pathologies and finally to design better treatment strategies. |
| Databáze: | OpenAIRE |
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