Association between serotonin 2A receptor genetic variations, stressful life events and suicide
| Autor: | Nasim Danaei, Morteza Seifi, Fatemeh Baybordi, Bahram Samadi Rad, Asghar Ghasemi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Rs6314 rs6311 Rs6313 Poison control Biology Iran Suicide prevention Polymorphism Single Nucleotide Life Change Events 03 medical and health sciences Young Adult 0302 clinical medicine Gene Frequency Polymorphism (computer science) Internal medicine Genotype Genetics medicine Humans Genetic Predisposition to Disease Receptor Serotonin 5-HT2A Allele frequency Aged General Medicine Middle Aged 030227 psychiatry Suicide Case-Control Studies Female 030217 neurology & neurosurgery Polymorphism Restriction Fragment Length Stress Psychological |
| Zdroj: | Gene. 658 |
| ISSN: | 1879-0038 |
| Popis: | Aim Life events are series of events that disrupt a person's psychological equilibrium and may enhance the development of a disorder such as suicide. Several studies have assessed a relationship between 5-hydroxytryptamine (serotonin) 2A receptor (5-HTR2A) gene polymorphisms with an increased risk of suicide. However, there has been no study about the association between three 5-HTR2A gene polymorphisms, A1438G (rs6311), T102C (rs6313) and C1354T (rs6314), suicide, stressful life, and loss events in a same time. Methods Relatives of 191 suicide victims were interviewed using a semi-structured questionnaire designed according to Iranian culture. Venous blood was taken from all subjects for DNA isolation. 5-HTR2A polymorphisms in a total of 191 suicide victims and 218 healthy controls were genotyped using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). Chi-squared and Fisher's exact tests were used to compare genotype and allele frequencies between suicide and control groups. Correction for multiple comparisons was calculated using Bonferroni correction. Results There was a significant association between the 102 C/C genotype of 5-HTR2A gene and suicide (к2 = 8.700, P = 0.012). Furthermore, we found that suicide victims with a 102 C/C genotype had a significantly higher number of stressful life and loss events (P 0.05). Conclusion Our results suggest that C102T (rs6313) polymorphism of 5-HTR2A gene may be involved in the susceptibility to suicide, higher number of stressful life and loss events, but A1438G (rs6311) and C1354T (rs6314) polymorphisms of 5-HTR2A gene were not associated with suicide, higher number of stressful life and loss events. |
| Databáze: | OpenAIRE |
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