Absence of up-regulation for a proliferation-inducing ligand in Sjögren's sialadenitis lesions
| Autor: | Jacques-Olivier Pers, Carlo Chizzolini, Bertrand Huard, Tommaso Lombardi, Alexander Tzankov, Solange Moll, Marie-Laure Santiago-Raber, Pierre Youinou, Cem Gabay |
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| Přispěvatelé: | Laboratory of Oral Histopathology, Division of Stomatology, Faculty of Medicine, Department of Pathology, Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Laboratoire d'Immunologie et Immunothérapie, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Institute of Pathology, University Hospital Basel [Basel], Division of Rheumatology, University Hospital, University Hospital Brisel, Immunology and Allergy, University Hospital and School of Medicine, Division of Hematology, Geneva University Hospital (HUG) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Pathology ddc:616.07 0302 clinical medicine Tumor Necrosis Factor Ligand Superfamily Member 13/genetics/metabolism MESH: Up-Regulation Pharmacology (medical) B-cell lymphoma Sialadenitis/complications/metabolism/pathology Cells Cultured ddc:616 MESH: Aged 0303 health sciences MESH: Plasma Cells MESH: Middle Aged biology Biopsy Needle MESH: Sialadenitis MESH: Tumor Necrosis Factor Ligand Superfamily Member 13 Middle Aged Immunohistochemistry ddc:617.6 Salivary Glands Minor/pathology 3. Good health Up-Regulation Sjogren's Syndrome medicine.anatomical_structure MESH: Cell Survival 030220 oncology & carcinogenesis [SDV.IMM]Life Sciences [q-bio]/Immunology Tumor necrosis factor alpha Female medicine.symptom Antibody Sjogren's Syndrome/complications/metabolism/pathology MESH: Cells Cultured Adult medicine.medical_specialty MESH: Biopsy Needle Cell Survival Plasma Cells Tumor Necrosis Factor Ligand Superfamily Member 13 Inflammation Salivary Glands Minor Sensitivity and Specificity Sialadenitis Sampling Studies Lesion 03 medical and health sciences Rheumatology MESH: Sampling Studies MESH: Cell Proliferation medicine Humans Plasma Cells/cytology/metabolism 030304 developmental biology Aged Cell Proliferation Autoimmune disease MESH: Humans business.industry MESH: Adult MESH: Immunohistochemistry medicine.disease MESH: Salivary Glands Minor Epithelium MESH: Sensitivity and Specificity MESH: Male MESH: Sjogren's Syndrome biology.protein business MESH: Female |
| Zdroj: | Rheumatology Rheumatology, Oxford University Press (OUP), 2011, 50 (7), pp.1211-5. ⟨10.1093/rheumatology/ker016⟩ Rheumatology, Vol. 50, No 7 (2011) pp. 1211-5 Rheumatology (Oxford England) |
| ISSN: | 1462-0324 1460-2172 |
| DOI: | 10.1093/rheumatology/ker016⟩ |
| Popis: | International audience; OBJECTIVE: To determine whether a proliferation-inducing ligand (APRIL) has a role in the survival of plasma cells infiltrating salivary glands from SS patients. METHODS: We performed immunological staining for APRIL in minor salivary glands from SS with a pair of antibodies specifically recognizing APRIL-producing cells and secreted APRIL. RESULTS: Despite high leucocyte infiltration, APRIL-producing cells, identified as neutrophils, were rare in SS salivary glands. Keratinocytes from the adjacent oral epithelium also produced APRIL, but we never detected significant levels of secreted APRIL in SS salivary glands. We obtained similar results with B-cell lymphomas associated with SS. In fact, there was no significant difference in APRIL production and the level of secreted APRIL in these pathological samples compared with normal corresponding tissues. CONCLUSION: The combined observation that APRIL production is not up-regulated in lesions from SS patients, and that secreted APRIL is not retained in these lesions, indicates that plasma cells frequently present in SS lesions may not rely on APRIL for survival, as they do in other rheumatic diseases. |
| Databáze: | OpenAIRE |
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