Evaluation of effectiveness of antiandrogen treatments on cavernosal tissues in rats
| Autor: | Bilal Günaydın, Bekir Suha Parlaktas, Fatma Markoç, Adem Yaşar, Fikret Erdemir, Fatih Firat |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Urology 030232 urology & nephrology Administration Oral Pressure response Antiandrogen Gonadotropin-Releasing Hormone Tosyl Compounds 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Smooth muscle Erectile Dysfunction Antineoplastic Combined Chemotherapy Protocols Nitriles Medicine Animals Humans Anilides Orchiectomy Rats Wistar Pathological 030219 obstetrics & reproductive medicine business.industry Prostatic Neoplasms Androgen Antagonists Muscle Smooth General Medicine Rats Disease Models Animal Castration chemistry Antiandrogen Treatment Goserelin Collagen business Penis |
| Zdroj: | AndrologiaREFERENCES. 52(5) |
| ISSN: | 1439-0272 |
| Popis: | In this study, we aimed to compare changes in cavernosal tissues in rats with antiandrogen treatment and orchiectomy. A total of 42 Wistar albino rats were divided into four groups. Group I, control group, Group II, LH-RH was given for 1 month, Group III-LH-RH + Bicalutamide was given for 1 month, and Group IV was defined as orchiectomy and followed up for 1 month. Measurements of intracavernosal pressure with different electrical stimuli and pathological findings of smooth muscle collagen in cavernosal tissues were examined. While the cavernosal pressure response in all the different electrical stimuli given in the control group and in all other groups was significantly lower than that in the other groups, it was statistically significant at 7.5 and 10 V (p = .005, p |
| Databáze: | OpenAIRE |
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