Hybrid Polydimethylsiloxane Bioscaffold-Intravascular Catheter for Cellular Therapies
| Autor: | Avnesh S. Thakor, Jing Wang, Rosita Primavera, Mehdi Razavi, Sophia Hu, Anirudh Avadhani |
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| Rok vydání: | 2022 |
| Předmět: |
endocrine system
geography Pathology medicine.medical_specialty geography.geographical_feature_category endocrine system diseases business.industry Insulin deficiency Pancreatic islets Biochemistry (medical) Biomedical Engineering nutritional and metabolic diseases General Chemistry medicine.disease Islet Biomaterials Transplantation Catheter medicine.anatomical_structure Intravascular catheter Diabetes mellitus Medicine business |
| Zdroj: | ACS applied bio materials. 3(10) |
| ISSN: | 2576-6422 |
| Popis: | Type-1 diabetes (T1D) is caused by immune-mediated destruction of insulin-producing beta-cells, resulting in insulin deficiency and hyperglycemia. Islet transplantation is a potential treatment for T1D, but clinical implementation is hampered by islet availability and poor islet survival post-transplantation. To overcome these issues, we developed an intravascular multiside hole catheter with an interior polydimethylsiloxane (PDMS) bioscaffold capable of housing a cellular cargo. We used computational fluid dynamics to determine an optimized catheter design, which we then fabricated. Using our hybrid PDMS bioscaffold-intravascular catheter, we demonstrated that this platform can successfully maintain |
| Databáze: | OpenAIRE |
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