Nerve sheath myxoma (neurothekeoma) arising in the oral cavity: histological and immunohistochemical features of 3 cases
| Autor: | Lihong Wang, Kiyoko Nagumo, Ayataka Ishikawa, Norihiko Okada, Mai Nishioka, Rodelio L. Aguirre |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Pathology medicine.medical_specialty Enolase Receptors Nerve Growth Factor Schwannoma Biology Neurothekeoma medicine Humans Receptor General Dentistry Actin S100 Proteins Myxoma Anatomy Middle Aged SMA medicine.disease Cheek Otorhinolaryngology Child Preschool Phosphopyruvate Hydratase Immunohistochemistry Surgery Female Mouth Neoplasms Oral Surgery |
| Zdroj: | Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 107(5) |
| ISSN: | 1528-395X |
| Popis: | This report describes the histological and immunohistochemical characteristics of 3 cases of nerve sheath myxoma (NSM)/neurothekeoma arising in the oral cavity. Histopathologically, 3 distinct variants were observed based on the amount of myxoid matrix: classic/hypocellular, cellular, and mixed types. Immunohistochemically, all types expressed strong immunoreactivity to S-100 protein (3/3), NSE (neuron-specific enolase) (3/3), and NGFR (nerve growth factor receptor) (3/3), whereas all cases were negative for SMA (smooth muscle actin) and FVIII. The number of Ki-67 positive cells was less than 5% in all lesions confirming the slow growing characteristics of NSM. The results suggest that NSMs of the oral cavity are true peripheral nerve sheath tumors and show close relationship to schwannoma. |
| Databáze: | OpenAIRE |
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