The Use of Immunosuppressant Therapy for Multiple Sclerosis in Italy: A Multicenter Retroprospective Study
| Autor: | Emanuele D'Amico, Carlo Pozzilli, Vito Lepore, Giacomo Lus, Francesco Patti, Carmela Leone, Giusi Graziano, Roberto Bergamaschi, Maria Trojano, Franco Granella, Gioacchino Tedeschi, Enrico Millefiorini, Maria Teresa Ferrò, Alessandra Lugaresi, Mario Zappia, Maria Pia Amato, Giancarlo Comi, Paola Cavalla, Enrico Granieri, G. Coniglio, Giancarlo Di Battista |
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| Přispěvatelé: | Emanuele D’Amico, Carmela Leone, Giusi Graziano, Maria Pia Amato, Roberto Bergamaschi, Paola Cavalla, Gabriella Coniglio, Giancarlo Di Battista, Maria Teresa Ferrò, Franco Granella, Enrico Granieri, Alessandra Lugaresi, Giacomo Lu, Enrico Millefiorini, Carlo Pozzilli, Gioacchino Tedeschi, Mario Zappia, Giancarlo Comi, Maria Trojano, Vito Lepore, Francesco Patti, D'Amico, Emanuele, Leone, Carmela, Graziano, Giusi, Amato, Maria Pia, Bergamaschi, Roberto, Cavalla, Paola, Coniglio, Gabriella, Di Battista, Giancarlo, Ferrò, Maria Teresa, Granella, Franco, Granieri, Enrico, Lugaresi, Alessandra, Lus, Giacomo, Millefiorini, Enrico, Pozzilli, Carlo, Tedeschi, Gioacchino, Zappia, Mario, Comi, Giancarlo, Trojano, Maria, Lepore, Vito, Patti, Francesco, D'Amico, E, Leone, C, Graziano, G, Amato, Mp, Bergamaschi, R, Cavalla, P, Coniglio, G, Di Battista, G, Ferrò, Mt, Granella, F, Granieri, E, Lugaresi, A, Lus, G, Millefiorini, E, Pozzilli, C, Tedeschi, G, Zappia, M, Trojano, M, Lepore, V, Patti, F. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Economics lcsh:Medicine Social Sciences Azathioprine Pharmacology Off-label use Biochemistry Geographical Locations 0302 clinical medicine Mathematical and Statistical Techniques Medicine and Health Sciences Ethnicities 030212 general & internal medicine lcsh:Science education.field_of_study Multidisciplinary Pharmaceutics Medicine (all) Drugs Neurodegenerative Diseases Immunosuppressives Italian People Europe Neurology Italy Physical Sciences Regression Analysis Female Multiple Sclerosis Immunosuppressant Therapy Italy Multicenter Retroprospective Study Statistics (Mathematics) Immunosuppressive Agents medicine.drug Research Article Adult medicine.medical_specialty Multiple Sclerosis Population Immunology Research and Analysis Methods Autoimmune Diseases 03 medical and health sciences Pharmacotherapy Health Economics Drug Therapy Internal medicine medicine Humans Medical prescription Statistical Methods education Retrospective Studies Immunosuppression Therapy multiple sclerosis therapy Biochemistry Genetics and Molecular Biology (all) business.industry Multiple sclerosis lcsh:R Ambientale Biology and Life Sciences Proteins Retrospective cohort study medicine.disease Demyelinating Disorders Clinical trial Health Care Agricultural and Biological Sciences (all) Immunosuppressant Therapy Multicenter Retroprospective Study People and Places lcsh:Q Clinical Immunology Population Groupings Interferons Clinical Medicine business 030217 neurology & neurosurgery Mathematics |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 6, p e0157721 (2016) |
| ISSN: | 1932-6203 |
| Popis: | Introduction Immunosuppressive agents (ISA) have been used in multiple sclerosis (MS) for decades, frequently as off label licensed therapies. Given the new MS treatment landscape, what place do ISA have in combating MS? Methods We conducted a retrospective multicentre study to investigate the frequency of ISA prescription in 17 Italian MS centres, and to describe the clinical factors related to ISA use. Results Out of 6,447 MS patients, 2,034 (31.6%) were treated with ISA, with Azathioprine being the most frequently used ISA overall. MS patients treated with ISA alone were more frequently affected by the progressive course (both primary and secondary) of the disease (RRR 5.82, 95% CI 4.14–8.16, p |
| Databáze: | OpenAIRE |
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