Phytochemistry And Some Haematological Changes Following Oral Administration Of Ethanolic Root Extract Of Gonglonema Latifolium In Rats
| Autor: | AB Antai, S. O. Ukafia, E A Agiang, DE Ikpi, Ofem Effiong Ofem |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Blood Platelets
Erythrocyte Indices Erythrocytes Administration Oral Biology Hematocrit Plant Roots Hemoglobins Leukocyte Count Alkaloids Phenols Oral administration Leukocytes medicine Animals Glycosides Rats Wistar Flavonoids chemistry.chemical_classification Blood Cells Dose-Response Relationship Drug Ethanol Apocynaceae Traditional medicine medicine.diagnostic_test Plant Extracts Polyphenols Glycoside General Medicine Gonglonema latifolium root extract Phytochemistry blood Eosinophil biology.organism_classification Rats Dose–response relationship medicine.anatomical_structure chemistry Phytochemical Polyphenol Erythrocyte Count Solvents |
| Zdroj: | Nigerian Journal of Physiological Sciences; Vol 24, No 1 (2009) |
| ISSN: | 0794-859X |
| DOI: | 10.4314/njps.v24i1.46388 |
| Popis: | Gongronema latifolium is a climbing perennial plant that belongs to the family of asclepidaceae. The medicinal uses of the leaves and stem bark extract of Gongronema latifolium has been reported in many scientific literatures to include anti-hyperglycaemic, anti-ulcerative etc. There is paucity in scientific reports on the medicinal properties of the root extract. This study was therefore designed to elucidate the phytochemical constituents and effect of ethanolic root extract of Gongronema latifolium on some hematological parameters. Eighteen (18) albino Wistar rats were randomly assigned into 3 groups of 6 rats each. Group 1 [control] was fed on normal rat chow, the test groups [group 2 and 3] in addition received extract treatment [p.o] at a dose of 100mg/kg and 200mg/kg respectively. The feeding regimens lasted for 14 days and all animals had access to tap water. Results show that the extract contains polyphenols, glycosides, reducing sugars and alkaloids. The mean RBC count for control was 4.44+/-0.15x10(6)cells/mm3, this did not differ significantly from the test groups. The total WBC counts were 3.79+/-0.15x10(3) cells/mm3, 3.37+/-0.19x10(3)cells/mm3 and 5.54+/-0.39x10(3)cells/mm3 for groups 1, 2, and 3 respectively. WBC was significantly [P |
| Databáze: | OpenAIRE |
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