Survival Analysis in Patients With Preserved Left Ventricular Function and Standard Indications for Permanent Cardiac Pacing Randomized to Right Ventricular Apical or Septal Outflow Tract Pacing
| Autor: | Justyna Staniewicz, Ewa Lewicka-Nowak, Rajmund Wilczek, Dariusz Kozłowski, Grzegorz Raczak, Anna Faran, Sebastian Tybura, Paweł Zagożdżon, G. Swiatecka, Alicja Dabrowska-Kugacka |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Time Factors Heart Ventricles Kaplan-Meier Estimate Ventricular Septum Risk Assessment Ventricular Function Left law.invention Randomized controlled trial law Humans Medicine Prospective Studies Prospective cohort study Survival analysis Aged Proportional Hazards Models Heart Failure Proportional hazards model business.industry Hazard ratio Cardiac Pacing Artificial Stroke Volume Atrial fibrillation General Medicine Stroke volume Middle Aged medicine.disease Confidence interval Radiography Treatment Outcome Anesthesia Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation Journal. 73:1812-1819 |
| ISSN: | 1347-4820 1346-9843 |
| DOI: | 10.1253/circj.cj-09-0084 |
| Popis: | Background: Optimal right ventricular (RV) pacing site in patients referred for permanent cardiac pacing remains controversial. A prospective randomized trial was done to compare long-term effect of permanent RV apex (RVA) vs RV outflow tract (RVOT) pacing on the all-cause and cardiovascular mortality. Methods and Results: A total of 122 consecutive patients (70 men, 69 ±11 years), with standard pacing indications were randomized to RVA (66 patients) or RVOT (56 patients) ventricular lead placement. After the 10-year follow-up period the mortality data were summarized on the basis of an intention-to-treat analysis. During the long-term follow-up, 31 patients from the RVA group died vs 24 patients in the RVOT group (hazard ratio (HR), 0.96; 95% confidence interval (CI), 0.57-1.65; P=0.89). There were 10 cardiovascular deaths in the RVA and 12 in the RVOT group (HR, 1.04; 95%CI, 0.45-2.41; P=0.93). There were no differences in the all-cause or cardiovascular mortality between the pacing sites after adjustment for age, gender, arterial hypertension, atrial fibrillation, New York Heart Association class and left ventricular end-diastolic diameter. Conclusions: The RVOT provides no additional benefit in terms of long-term survival over RVA pacing. (Circ J 2009; 73: 1812-1819) |
| Databáze: | OpenAIRE |
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