The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review
| Autor: | Maya Williams, Lucy C. Fairclough, Ian Todd |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Allergy Neurology Exacerbation Cytotoxic T cell Immunology Population Review CD8-Positive T-Lymphocytes CD8 + T lymphocyte 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine Internal medicine medicine Humans education Pharmacology education.field_of_study COPD business.industry Chronic obstructive pulmonary disease Smoking medicine.disease Rheumatology 030104 developmental biology 030228 respiratory system Lung disease Cytokines business CD8 |
| Zdroj: | Inflammation Research |
| ISSN: | 1420-908X 1023-3830 |
| Popis: | Objective and design This systematic review aims to establish the role of CD8 + T lymphocytes in COPD. Methods Forty-eight papers published in the last 15 years were identified for inclusion. Results CD8 + T-cells are increased in the lungs of patients with COPD (17 studies, 16 positive) whereas in the circulation, findings were inconclusive. Activation of CD8 + T-cells was enhanced in lungs (four studies, three positive) but cell phenotype was unclear. There was substantial evidence of a higher proportion of type 1 CD8 + (Tc1) cells in COPD (11 studies, 9 positive), though the population of type 2 (Tc2) cells was also increased (5 studies, 4 positive). CD8 + T-cells in COPD exhibited greater expression of cytotoxic proteins (five studies, five positive). Studies assessed a variety of questions so evidence was insufficient to draw firm conclusions. The role of CD8 + T-cells at acute exacerbation of COPD and also their contribution to alveolar destruction can only be hypothesised at this stage. Conclusions Not only is the number of CD8 + T-cells increased in COPD, these cells have increased capacity to exert effector functions and are likely to contribute to disease pathogenesis. Several mechanisms highlighted show promise for future investigation to consolidate current knowledge. |
| Databáze: | OpenAIRE |
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