Clinical efficacy of a triclosan/copolymer/NaF dentifrice and a commercially available breath-freshening dentifrice on hydrogen sulfide-forming bacteria

Autor: Shira Pilch, MI Williams, Diane Cummins, Joe Vazquez
Rok vydání: 2005
Předmět:
Zdroj: Oral Diseases. 11:64-66
ISSN: 1601-0825
1354-523X
DOI: 10.1111/j.1601-0825.2005.01095.x
Popis: Objective The objective of this double blind clinical study was to compare the 4-h and overnight effects of a triclosan/copolymer/fluoride (TCF) dentifrice and a commercially available breath freshening (CBF) dentifrice containing fluoride for their ability to control H2S-forming bacteria. Methods Following a one-week washout period of brushing with a regular fluoride dentifrice, subjects reported to the clinical site without performing oral hygiene, eating or drinking in preparation for baseline saliva sampling. After providing a baseline saliva sample, subjects were randomly assigned a test dentifrice and instructed to brush their teeth for one minute, twice a day for one week. On the morning of the 8th day, subjects returned to the test site having refrained from oral hygiene, eating and drinking for overnight sampling. Subjects then brushed for 1 min with the assigned dentifrice, and returned for 2- and 4-h postbrushing evaluations. Following a second one-week washout, subjects repeated the same regimen, but now using the other dentifrice. Oral micro-flora samples were collected by subjects rinsing with 10 ml of sterile water for 10 s. Each collected sample was serially diluted and plated in duplicate onto lead acetate agar. After incubating for 72 h, dark colonies were counted, expressed as log colony-forming units ml−1, and reductions from baseline were calculated. Results Compared to baseline, the TCF dentifrice reduced H2S-forming bacteria 0.82, 0.80 and 0.22 log units at the 2-, 4- and 12-h time points compared to 0.60, 0.43 and 0.07 log units for the CBF dentifrice. The TCF dentifrice was statistically significantly better (P
Databáze: OpenAIRE
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