THYMUS IN HASHIMOTO'S DISEASE AND FOCAL CHRONIC LYMPHOID THYROIDITIS
| Autor: | Kashu Shimabukuro, Masaharu Tsuchiya, Hiroshi Yoshimatsu, Ken Kurita, Yoshio Mizuno |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty endocrine system diseases Hashimoto's disease business.industry medicine.medical_treatment Thyroid Thyroiditis Autoimmune Thymus Gland General Medicine Hyperplasia Plasma cell medicine.disease Thyroiditis Thymectomy medicine.anatomical_structure Immunology medicine Humans Thyroglobulin business Chronic thyroiditis |
| Zdroj: | The Keio Journal of Medicine. 24:275-287 |
| ISSN: | 1880-1293 0022-9717 |
| DOI: | 10.2302/kjm.24.275 |
| Popis: | Histological findings of the thymuses extirpated in 15 cases of Hashimoto's disease and 27 cases of focal chronic lymphoid thyroiditis were described. Hyperplasia of spindle-shaped epithelial cells were more prominent in the thymus of Hashimoto's disease (9/15, 60.0%). Thymic lymphoid follicles were demonstrated more frequently in focal chronic lymphoid thyroiditis (22/27, 81.5%). Plasma cell, which was ascertained by Methyl Green Pyronin stain was found in 10 out of 15 cases with Hashimoto's disease (66.6%) and in 16 out of 27 cases with focal chronic lymphoid thyroiditis (59.3%).The incidence of mononuclear cell which contained immunoglobulin or gammaglobulin in the thymuses was 62.5% (5 out of 8 patients) and 66.6% (4 out of 6 patients) in Hashimoto's disease and focal chronic thyroiditis, respectively.A long-term observation after thymectomy disclosed that the titrations of antibodies to thyroglobulin as well as thyroid microsome gradually decreased and came negative within one or two years, particularly in focal chronic lymphoid thyroiditis.It might be concluded that the thymus of Hashimoto's disease and focal chronic lymphoid thyroiditis was involved in proliferation of antibody forming cells and providing antigen reactive cells to induce immunopathy of thyroid and any other tissues. |
| Databáze: | OpenAIRE |
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