Functional Expression of the Amplification Reaction Between Serotonin and Epinephrine on Platelets
| Autor: | B. Xhonneux, Fred De Clerck, Didier de Chaffoy de Courcelles |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Blood Platelets
Serotonin medicine.medical_specialty Epinephrine Platelet Aggregation Platelet aggregation Stimulus (physiology) Adenosine Triphosphate In vivo Functional expression Internal medicine medicine Humans Platelet Receptor Pharmacology Chemistry Drug Synergism Receptors Adrenergic alpha Thromboxane B2 Endocrinology Receptors Serotonin Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 11:S1-S5 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-198800111-00002 |
| Popis: | Human platelet reactions are enhanced when a combination of serotonin and epinephrine is used as a stimulus. The amplification of the response operates through S2-serotonergic and alpha 2-adrenergic receptor subtypes. The first wave of platelet aggregation, which is independent of platelet release products, is enhanced while the latency period for the occurrence of release reaction and prostaglandin biosynthesis is shortened. Synergism between serotonin and epinephrine on the platelet occurs at low concentration of agonists and may contribute to the formation of an arterial thrombus in vivo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|