Analysis of Potential Oral Cleft Risk Factors in the Kosovo Population
| Autor: | Ramazan Isufi, Brett A. Ueeck, Nderim Salihaj, Hysni Arifi, Agreta Geci, Osman Sejfija, Milaim Sejdini, Blerim Krasniqi, Sami Salihu, Nijazi Heta |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Offspring Cleft Lip Population Kosovo Dentistry Logistic regression medicine.disease_cause Risk Factors Heredity Odds Ratio Medicine Humans education Pregnancy education.field_of_study Oral cleft business.industry Obstetrics Infant Newborn Odds ratio medicine.disease Confidence interval Cleft Palate Logistic Models Case-Control Studies Surgery Female business Paediatric Surgery |
| Popis: | The aim of this study was to analyze the association of potential risk factors such as positive family cleft history, smoking, use of drugs during pregnancy, and parental age with oral clefts in offspring within the Kosovo population. We conducted a population-based case-control study of live births in Kosovo from 1996 to 2005. Using a logistic regression model, 244 oral cleft cases were compared with 488 controls. We have excluded all syndromic clefts. Heredity increases the risk of clefts in newborns [odds ratio (OR) = 8.25, 95% confidence interval (CI) 3.12–23.52]. Clefts were also associated with smoking (OR = 1.87, 95% CI 0.75–4.08), use of drugs during pregnancy (OR = 2.25, 95% CI 0.82–5.12), increasing maternal age (OR = 1.83, 95% CI 1.42–2.49), and increasing paternal age (OR = 1.3, 95% CI 1.2– 1.4). We found heredity to be the most important factor for cleft occurrence in Kosovar newborns. Another significant potential risk factor for occurrence of clefts is the parental age. We found the use of drugs and smoking during pregnancy to be less significant. |
| Databáze: | OpenAIRE |
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