De novo generation of a functional human thymus from induced pluripotent stem cells

Autor:	Amiet R. Chhatta, Willem E. Fibbe, Karin Pike-Overzet, Françoise Carlotti, Frank J. T. Staal, Daniela C.F. Salvatori, Maaike Hanegraaf, Martijn Cordes, Jan J. Cornelissen, Tom Cupedo, Harald Mikkers, Sandra A. Vloemans, Rob C. Hoeben
Přispěvatelé:	Hematology
Rok vydání:	2019
Předmět:	0301 basic medicine medicine.medical_specialty Cellular differentiation Induced Pluripotent Stem Cells Transplantation Heterologous Immunology Morphogenesis Mice Nude Heterologous Thymus Gland Biology Organ transplantation Mice 03 medical and health sciences Organ Culture Techniques 0302 clinical medicine Immunity DiGeorge syndrome medicine Animals Humans Immunology and Allergy Induced pluripotent stem cell Cells Cultured Mice Knockout Cell Differentiation Forkhead Transcription Factors Organ Transplantation medicine.disease Transplantation 030104 developmental biology 030220 oncology & carcinogenesis Cancer research
Zdroj:	Journal of Allergy and Clinical Immunology, 144(5), 1416 Journal of Allergy and Clinical Immunology, 144(5), 1416-+. Mosby Inc.
ISSN:	0091-6749
DOI:	10.1016/j.jaci.2019.05.042
Popis:	A proper functional thymus is required for generation of T cell–mediated immunity. This is dramatically illustrated by patients lacking a thymus, such as children with complete DiGeorge syndrome, which is fatal if left untreated.1-3 Therapeutic options for such patients are limited and confined to transplantation of small fragments from allogeneic neonatal thymi.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468085f43577c943996bbc684372d176 https://doi.org/10.1016/j.jaci.2019.05.042 Zobrazit plný text záznamu Full Text from ScienceDirect