Pharmacokinetics of tulathromycin in edible tissues of healthy and experimentally infected pigs withActinobacillus pleuropneumoniae

Autor:	Anna Gajda, Tomasz Bladek, Andrzej Posyniak, Artur Jabłoński
Rok vydání:	2015
Předmět:	Pathology medicine.medical_specialty Swine Health Toxicology and Mutagenesis Cmax Disaccharides Toxicology Body weight Injections Intramuscular Andrology Actinobacillus Infections Pharmacokinetics Heterocyclic Compounds Injection site medicine Animals Tissue Distribution Tulathromycin Actinobacillus pleuropneumoniae Kidney biology Public Health Environmental and Occupational Health General Chemistry General Medicine biology.organism_classification medicine.anatomical_structure Case-Control Studies Intramuscular injection Food Analysis Food Science
Zdroj:	Food Additives & Contaminants: Part A. 32:1823-1832
ISSN:	1944-0057 1944-0049
Popis:	The aim of this study was the comparison of the tissue pharmacokinetics of tulathromycin in healthy pigs and pigs experimentally infected with Actinobacillus pleuropneumoniae (App). Tulathromycin was given to 24 healthy and 24 infected pigs by intramuscular injection at a single dosage of 2.5 mg kg(-1) body weight (b.w.). Pigs were euthanised at each group and then samples of liver, kidney, muscle, injection site and skin with fat were taken at scheduled time points. Drug concentrations were determined by LC-MS/MS. In this study, higher values of the area under the concentration-time curves (AUC) were calculated in all tissue samples taken from infected than healthy pigs. In pigs with App the AUCs of liver, kidney, muscle, skin with fat and injection site were 1111, 1973, 235, 181 and 2931 mg kg(-1) h, while in pigs without inflammation they were 509, 1295, 151, 111 and 1587 mg kg(-1) h, respectively. Maximum drug tissue concentrations (Cmax) in infected animals were 2370, 6650, 2016, 666 and 83,870 µg kg(-1), while in healthy pigs they were 1483, 6677, 1733, 509 and 55,006 µg kg(-1), respectively. The eliminations half-times (T1/2) were respectively longer in all tissue samples taken from infected animals (from 157.3 to 187.3 h) than in healthy ones (from 138.6 to 161.2 h). The tulathromycin tissue concentrations were significantly higher (p < 0.05) in all tissue samples of the infected pigs compared with the healthy animals at 360 h (from 0.0014 to 0.0280) and at 792 h (from 0.0007 to 0.0242) after drug administration. The results suggest that the tissue pharmacokinetic properties and residue depletion of tulathromycin can be influenced by the disease state of animals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467f1bbe37d01516314e5eb34722bc65 https://doi.org/10.1080/19440049.2015.1078915 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.