Cardio-protective and antioxidant properties of caffeic acid and chlorogenic acid: Mechanistic role of angiotensin converting enzyme, cholinesterase and arginase activities in cyclosporine induced hypertensive rats
| Autor: | Akintunde Afolabi Akindahunsi, Temitayo Olabisi Ajibade, Ademola Adetokunbo Oyagbemi, Odunayo Michael Agunloye, Adedayo O. Ademiluyi, Ayokunle O. Ademosun, Adeolu Alex Adedapo, Temidayo Olutayo Omobowale, Ganiyu Oboh |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Antifungal Agents Cardiotonic Agents Antioxidant medicine.medical_treatment RM1-950 Peptidyl-Dipeptidase A Pharmacology Antioxidants 03 medical and health sciences chemistry.chemical_compound Caffeic Acids 0302 clinical medicine Chlorogenic acid Oral administration Caffeic acid medicine Animals Cholinesterases cardiovascular diseases Cholinesterase Arginase biology Nitric oxide Angiotensin-converting enzyme Captopril General Medicine Rats Enzyme Activation 030104 developmental biology chemistry 030220 oncology & carcinogenesis Hypertension Blood pressure Cyclosporine biology.protein Therapeutics. Pharmacology Chlorogenic Acid medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 109, Iss, Pp 450-458 (2019) |
| ISSN: | 0753-3322 |
| Popis: | Caffeic acid (CAA) and chlorogenic acid (CHA) are important members of hydroxycinnamic acid with natural antioxidant and cardio-protective properties. The present study aimed to determine the effect of CAA and CHA on systolic blood pressure, heart rates (HR) as well as on the activity of the angiotensin-1-converting enzyme (ACE), acetylcholinesterase (AChE), butrylcholinesterase (BChE) and arginase in cyclosporine-induced hypertensive rats. Experimental rats were distributed into 7 groups (n = 6): normotensive control rats; hypertensive rats (induced rats) as well as hypertensive- treated groups with captopril (10 mg/kg/day), CAA (10 and 15 mg/kg/day) and CHA (10 and 15 mg/kg/day), respectively. The experiment lasted for 7 days and the systolic blood pressure (SBP) and heart rates were recorded using tail-cuff method. Oral administration of captopril, caffeic acid and chlorogenic acid normalized hypertensive effect caused by cyclosporine administration. CAA and CHA significantly (P |
| Databáze: | OpenAIRE |
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