Early Diagnostic Biomarkers of Sepsis for Patients with Acute-on-Chronic Liver Failure: A Multicenter Study
| Autor: | Xingwang Hu, Xiao-xiao Liu, Ze-Bing Huang, Li-Yuan Long, Jinjun Chen, Jun Chen, Zhiping Qian, Xin Zheng, Xue-Gong Fan, Hai Li, Cheng-Jin Liao, Xianbo Wang, Yan Huang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Myeloid 030106 microbiology Procalcitonin Sepsis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Diagnostic biomarker Acute on chronic liver failure 030212 general & internal medicine Original Research business.industry Presepsin Early diagnosis medicine.disease sTREM-1 Multicenter study Acute-on-chronic liver failure Infectious Diseases medicine.anatomical_structure SOFA score Complication business |
| Zdroj: | Infectious Diseases and Therapy |
| ISSN: | 2193-6382 2193-8229 |
| DOI: | 10.1007/s40121-020-00362-x |
| Popis: | Introduction Sepsis is a complication in acute-on-chronic liver failure (ACLF) patients associated with high rates of mortality and morbidity. Early diagnosis of sepsis in ACLF patients can improve prognosis. This study aimed to explore potential effective biomarkers for the early diagnosis of sepsis in ACLF patients. Methods Ninety-four ACLF patients with sepsis were enrolled from 10 hospitals across China from January 2015 to June 2016 as well as 49 ACLF patients without infection from Xiangya Hospital. The first-day admission data and SOFA score and CLIF-SOFA score were collected. The differences of indicators between groups were compared with Kruskal-Wallis test. The receiver-operating characteristic (ROC) curve was analyzed to evaluate the diagnostic efficiency of the selected factors. Results Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) and presepsin were significantly higher in ACLF-sepsis patients compared with ACLF patients with no infection (P |
| Databáze: | OpenAIRE |
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