Reduced body iron stores and atherosclerosis in patients with cyanotic congenital heart disease
| Autor: | Mark R. Goldstein, Francesca Pezzetta, Luca Mascitelli |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cyanosis
Heart Defects Congenital medicine.medical_specialty Heart disease business.industry Cyanotic congenital heart disease Iron Iron Deficiencies Hypoxia (medical) medicine.disease Atherosclerosis Hypoxemia Downregulation and upregulation Internal medicine medicine Cardiology Erythropoiesis Humans In patient Hypoxia-Inducible Factor 1 medicine.symptom Cardiology and Cardiovascular Medicine business Transcription factor |
| Zdroj: | International journal of cardiology. 146(1) |
| ISSN: | 1874-1754 |
| Popis: | Cyanotic patients with congenital heart disease have been shown to be protected against atherosclerosis [1,2]. The mechanisms underlying this association are not fully elucidated. We suggest that the erythropoietic adaptations with consequent changes in iron metabolism that occur when cyanotic patients are exposed to hypoxia may have an important role in reducing the development of atherosclerosis. The adaptive response to hypoxia is primarily mediated by the transcription factor hypoxia-inducible factor-1 (HIF-1) due to upregulation of an array of genes required for the adaptive response to low oxygen levels [3]. Indeed, it was found that the expression of HIF-1α (an oxygen-sensitive subunit of HIF-1) and global HIF-1 activity were elevated in the myocardium of infants with cyanotic congenital heart disease compared to those with acyanotic congenital heart disease, and that this response directly correlated with the degree of hypoxemia [4]. Iron plays a central role in the protection from hypoxemia, as it is incorporated in the newly synthesized haemoglobin throughout erythropoiesis. In this setting, it has been shown that |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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