Bronchial hyperreactivity to leucotriene D4 and histamine in exogenous asthma
| Autor: | F. Madsen, Steffen Groth, Hans Bisgaard |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Vital capacity Allergy Adolescent Vital Capacity Bronchi Peak Expiratory Flow Rate chemistry.chemical_compound Airway resistance Double-Blind Method Forced Expiratory Volume Humans Medicine General Environmental Science Maximal Expiratory Flow Rate Asthma Clinical Trials as Topic Dose-Response Relationship Drug Inhalation business.industry Airway Resistance General Engineering General Medicine medicine.disease respiratory tract diseases chemistry Immunology General Earth and Planetary Sciences Female SRS-A business Slow-reacting substance of anaphylaxis Histamine Research Article |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.290.6480.1468 |
| Popis: | Reactivity of the small and large airways to inhaled leucotriene D4, one of the leucotrienes that constitute slow reacting substance of anaphylaxis, was studied in eight patients with exogenous asthma and nine healthy subjects with no history of atopy. Non-cumulative dose response relations were constructed for leucotriene D4 in a randomised, double blind set up. Reactivity to the leucotriene was compared with reactivity to histamine in the two groups. Both groups reacted to leucotriene D4 with significant airway obstruction evident in forced expiratory volume in one second (FEV1), peak expiratory flow rate, maximal expiratory flow rate at 30% of forced vital capacity estimated from a partial flow volume curve initiated at 50% of vital capacity (V30), and an increase in volume of trapped gas. The airways of the patients were significantly (p less than 0.01) more reactive to leucotriene D4 than those of the controls. The differences were in order of magnitude, 10(2)-10(3) for FEV1 but only about 15 for V30 (p less than 0.05). The hyperreactivity of the airways of the asthmatic subjects to leucotriene D4 was comparable to that to histamine. Inhalation of leucotriene D4 caused pronounced dyspnoea only among the patients. The findings suggest a role for leucotriene D4 in human bronchial asthma. |
| Databáze: | OpenAIRE |
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