Model of β-Sheet of Muscle Fatty Acid Binding Protein of Locusta migratoria Displays Characteristic Topology
| Autor: | Jamal Alruwaili, Nadeem A. Kizilbash, Abdul Hai |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Portal hypothesis
Nuclear Overhauser Effect Stereochemistry β-sheet of Lm-FABP Beta sheet Locusta migratoria General Medicine Nuclear Overhauser effect Hypothesis Biology Ligand (biochemistry) Bioinformatics Nmr data Fatty acid-binding protein Muscle Fatty Acid Binding Protein Heart-type fatty acid binding protein Fatty Acid Binding Protein 3 |
| Zdroj: | Bioinformation |
| ISSN: | 0973-2063 0973-8894 |
| Popis: | The β-sheet of muscle fatty acid binding protein of Locusta migratoria (Lm-FABP) was modeled by employing 2-D NMR data and the Rigid Body Assembly method. The model shows the β-sheet to comprise ten β-strands arranged anti-parallel to each other. There is a β-bulge between Ser 13 and Gln 14 which is a difference from the published structure of β-sheet of bovine heart Fatty Acid Binding Protein. Also, a hydrophobic patch consisting of Ile 45, Phe 51, Phe 64 and Phe 66 is present on the surface which is characteristic of most Fatty Acid Binding Proteins. A "gap" is present between βD and βE that provides evidence for the presence of a portal or opening between the polypeptide chains which allows ligand fatty acids to enter the protein cavity and bind to the protein. |
| Databáze: | OpenAIRE |
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