Clinical results of image-guided interstitial brachytherapy with or without external beam radiotherapy for postsurgical vaginal recurrence of cervical and endometrial cancers
| Autor: | Ayano Horiuchi, Tadashi Sugita, Fumio Ayukawa, Kotaro Takahashi, Ayae Kanemoto, Kazufumi Haino, Akira Kikuchi |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Radiotherapy Planning Computer-Assisted Brachytherapy Interstitial brachytherapy Planning target volume Rate control Radiotherapy Dosage Endometrial Neoplasms Radiation therapy medicine Effective treatment Humans Radiology Nuclear Medicine and imaging Female Radiology External beam radiotherapy Neoplasm Recurrence Local business Pelvic radiotherapy Radiotherapy Image-Guided Retrospective Studies |
| Zdroj: | Japanese journal of radiology. 40(6) |
| ISSN: | 1867-108X |
| Popis: | Purpose This study aimed to evaluate the clinical outcome and efficacy of image-guided interstitial brachytherapy (ISBT) for postsurgical vaginal recurrence of cervical and endometrial cancers. Materials and methods The study included 11 patients who received CT-based image-guided high-dose-rate ISBT with or without external beam radiotherapy (EBRT). Local control, progression-free survival, and treatment-related toxicities were evaluated retrospectively. Results Of the 11 patients, 4 underwent ISBT with EBRT and the other 7 ISBT alone; two of the latter patients received previous pelvic radiotherapy. After a median follow-up of 43.9 months (range 3.9–92.7 months), the 2-year local control rate was 100%. The median equivalent doses in 2 Gy fractions received by at least 90% of the clinical target volume for ISBT with versus without EBRT were 82.2 Gy (range 60.4–84.2 Gy) versus 69.0 Gy (range 50.8–98.2 Gy). The 2-year progression-free survival rates after ISBT with versus without EBRT were 75% versus 80%, and the difference was not significant (p = 0.74). Grade 3 late toxicities occurred in two patients. Conclusion Our radiotherapy strategy using image-guided ISBT, either with or without EBRT, for postsurgical vaginal recurrence showed effective treatment outcomes. |
| Databáze: | OpenAIRE |
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