Influence of donor microbiota on the severity of experimental graft-versus-host-disease
| Autor: | Evelyn Nieves, Yaping Sun, Gabriel Núñez, Hiroya Tamaki, Isao Tawara, Chen Liu, Pavan Reddy, Rebecca Evers, Tomomi Toubai, Nathan Mathewson |
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| Rok vydání: | 2012 |
| Předmět: |
Microbial flora
Bone marrow transplantation Cellular differentiation T-Lymphocytes Graft vs Host Disease chemical and pharmacologic phenomena Disease macromolecular substances digestive system Severity of Illness Index Article 03 medical and health sciences Mice 0302 clinical medicine Immune system immune system diseases Severity of illness Medicine Animals Allogeneic 030304 developmental biology Bone Marrow Transplantation Cell Proliferation 0303 health sciences Transplantation Germ-free Bacteria business.industry Cell Differentiation Hematology medicine.disease 3. Good health Disease Models Animal Graft-versus-host disease surgical procedures operative 030220 oncology & carcinogenesis Immunology business |
| Zdroj: | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 19(1) |
| ISSN: | 1523-6536 |
| Popis: | The link between microbial flora and the shaping of immune responses is being increasingly appreciated, and recent data have uncovered a role for recipient microbiota in the severity of graft-versus-host disease (GVHD). The impact of donor microbiota on T cell–mediated alloresponses and GVHD is not known, however. Using multiple clinically relevant murine models, we analyzed the effect of donor microbiota on the severity of GVHD induced by T cells from specific pathogen-free and germ-free donors, and found that donor microbiota does not alter the expansion or differentiation of alloreactive T cells or the severity of GVHD. |
| Databáze: | OpenAIRE |
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