A three-month repeated oral administration study of a low viscosity grade of hydroxypropyl methylcellulose in rats
| Autor: | Hiroaki Muto, Ayako Yoshida, Mariko Hirata, Jyun-ichi Nagaya, Hitoshi Shigeno, Masatoshi Furukawa, Masao Sunaga, Sakae Obara |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Administration Oral Urine Methylcellulose Toxicology Eye Viscosity Eating Animal science Hypromellose Derivatives Sex Factors Oral administration medicine Animals Chemistry Body Weight Organ Size Surgery Rats Blood chemistry Toxicity Histopathology Female Viscosity index Blood Chemical Analysis |
| Zdroj: | The Journal of toxicological sciences. 24(1) |
| ISSN: | 0388-1350 |
| Popis: | The toxicity of the lowest viscosity grade of hydroxypropyl methylcellulose (HPMC) that is currently commercially available was investigated by means of a three-month repeated oral administration study in male and female Crj:CD (SD) IGS rats at doses of 505, 1,020 and 2,100 mg/kg/day. Body weights of males and females in the 2,100 mg/kg group were lower than those of the control group on and after day 28 of administration, but the differences were not statistically significant. The degree of suppression of body weight gain in males was higher than that in females. This tendency was similar to the results in other toxicity studies of HPMC that have been reported. Males in the 2,100 mg/kg group showed a tendency (not significant) for decreased food consumption and urine volume. Examinations of general signs, hematology, blood chemistry, ophthalmology, absolute and relative organ weights, autopsy and histopathology revealed only a few, apparently coincidental, statistically significant differences from the control, and no evidence of any dose-dependent changes was found. It was concluded that the lowest viscosity grade of HPMC showed extremely low toxicity under the conditions of this study, as has been found for higher viscosity grades. |
| Databáze: | OpenAIRE |
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