Interleukin-6 produces neuronal loss in developing cerebellar granule neuron cultures
| Autor: | Donna L. Gruol, Lely A. Quina, C. L. Ur, Vi Nguyen, Penney Blakely-Gonzales, Jeffrey G. Netzeband, Shannon M. Conroy, Anne L. Prieto |
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| Rok vydání: | 2004 |
| Předmět: |
N-Methylaspartate
Cell Survival medicine.medical_treatment Neurotoxins Immunology Neuropathology Biology Receptors N-Methyl-D-Aspartate Neuroprotection Rats Sprague-Dawley Cerebellar Cortex medicine Animals Immunology and Allergy Drug Interactions Receptor Interleukin 6 Cells Cultured Neurons Cell Death Interleukin-6 Granule (cell biology) Neurotoxicity medicine.disease Rats Cytokine Animals Newborn nervous system Neurology biology.protein NMDA receptor Neurology (clinical) Neuroscience |
| Zdroj: | Journal of Neuroimmunology. 155:43-54 |
| ISSN: | 0165-5728 |
| Popis: | CNS levels of the cytokine interleukin-6 (IL-6) are elevated during CNS injury and disease, but it is unclear if IL-6 contributes to the pathologic process. Our studies show that in a well-characterized CNS developmental model system, primary cultures of rodent cerebellar granule neurons, chronic exposure to IL-6 during neuronal development can result in cell damage and death in a subpopulation of developing granule neurons. Chronic exposure to IL-6 also increased the susceptibility of the granule neurons to a toxic insult produced by excessive activation of NMDA receptors. These results are consistent with a role for IL-6 in the neuropathology observed in the developing CNS during injury and disease. |
| Databáze: | OpenAIRE |
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