Peptide and non‐peptide mimetics as potential therapeutics targeting oral bacteria and oral biofilms
| Autor: | Maryta Sztukowska, Donald R. Demuth, Mohammad Roky |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) antimicrobial peptide Peptidomimetic 030106 microbiology Immunology Antimicrobial peptides Peptide Microbial Sensitivity Tests Dental Caries Microbiology 03 medical and health sciences 0302 clinical medicine Humans Periodontitis targeted therapeutics General Dentistry chemistry.chemical_classification Mouth Invited Review Bacteria biology Microbiota Biofilm 030206 dentistry biology.organism_classification Antimicrobial Small molecule In vitro Anti-Bacterial Agents chemistry Biochemistry peptidomimetics Biofilms Peptides |
| Zdroj: | Molecular Oral Microbiology |
| ISSN: | 2041-1014 2041-1006 |
| DOI: | 10.1111/omi.12267 |
| Popis: | The development of the oral biofilm requires a complex series of interactions between host tissues and the colonizing bacteria as well as numerous interspecies interactions between the organisms themselves. Disruption of normal host–microbe homoeostasis in the oral cavity can lead to a dysbiotic microbial community that contributes to caries or periodontal disease. A variety of approaches have been pursued to develop novel potential therapeutics that are active against the oral biofilm and/or target specific oral bacteria. The structure and function of naturally occurring antimicrobial peptides from oral tissues and secretions as well as external sources such as frog skin secretions have been exploited to develop numerous peptide mimetics and small molecule peptidomimetics that show improved antimicrobial activity, increased stability and other desirable characteristics relative to the parent peptides. In addition, a rational and minimalist approach has been developed to design small artificial peptides with amphipathic α‐helical properties that exhibit potent antibacterial activity. Furthermore, with an increased understanding of the molecular mechanisms of beneficial and/or antagonistic interspecies interactions that contribute to the formation of the oral biofilm, new potential targets for therapeutic intervention have been identified and both peptide‐based and small molecule mimetics have been developed that target these key components. Many of these mimetics have shown promising results in in vitro and pre‐clinical testing and the initial clinical evaluation of several novel compounds has demonstrated their utility in humans. |
| Databáze: | OpenAIRE |
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