Blood cell superoxide dismutase and enolase activities as markers of alcoholic and nonalcoholic liver diseases
| Autor: | S. Doffoel, M. Doffoel, Marc Ledig, P. Kopp, Paul Mandel, R. Bockel |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Health (social science) Enolase Biology Toxicology Biochemistry Blood cell Superoxide dismutase Behavioral Neuroscience chemistry.chemical_compound Liver disease Internal medicine medicine Humans Xanthine oxidase Liver Diseases Alcoholic Aged Liver injury Blood Cells Superoxide Dismutase Liver Diseases Acetaldehyde General Medicine Middle Aged medicine.disease Alcoholism medicine.anatomical_structure Endocrinology Neurology chemistry Phosphopyruvate Hydratase Toxicity biology.protein Biomarkers |
| Zdroj: | Alcohol. 5:387-391 |
| ISSN: | 0741-8329 |
| DOI: | 10.1016/0741-8329(88)90025-0 |
| Popis: | Monitoring of chronic alcoholism would be facilitated by using sensitive biochemical markers in blood cells, mainly to detect differences between alcoholic subjects with or without liver injury. We propose two types of markers: the first one is superoxide dismutase (SOD) activity involved in the conversion of superoxide radicals (O2 •- ) formed during acetaldehyde oxidation by xanthine oxidase after chronic alcohol consumption; the second one is enolase activity with both isoenzyme forms: nonneuronal enolase (NNE) and neuron specific enolase (NSE) which has been shown to be modified in many injuries related to the glycolytic pathways. For SOD activity we found a significant increase in alcoholic patients with liver injury and mainly in cirrhotic patients with ascitis. Both enolase activities were also found to be significantly increased in alcoholic patients with liver injury but NNE activity was also increased in alcoholics without apparent liver disease. Our results suggest that increased activity of SOD and NSE in blood cells may be related to liver injury mainly in alcoholism while increased NNE activity may also be a marker of alcohol abuse without liver injury. |
| Databáze: | OpenAIRE |
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