Palladium(II) complexes of 5-substituted isatin thiosemicarbazones: Synthesis, spectroscopic characterization, biological evaluation and in silico docking studies
| Autor: | Kothapalli Bannoth Chandrasekhar, Gandham Munikumari, Venkata Bharat Nishtala, Laxma Reddy Kotha, Ramaiah Konakanchi, Chennuru Ramachandraiah, G. Ramesh |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Synthetic Communications. 49:146-158 |
| ISSN: | 1532-2432 0039-7911 |
| DOI: | 10.1080/00397911.2018.1546400 |
| Popis: | Substituted heterocyclic (isatin) appended thiosemicarbazone ligands (L1–L3) are synthesized by condensation of substituted isatin molecule with N(4)-phenyl-3-thiosemicarbazide in good yields. The palladium(II) complexes are synthesized from ligands (L1–L3) and PdCl2, with a general formula [PdCl(X-C15H10N4OS)] where X = 5-chloro (1), 5-bromo (2), and 5-nitro (3). Both analytical and spectroscopic methods have been used for the analysis and characterization of the synthesized compounds. The antimicrobial activity results observed that complexes, 1 and 2 have registered potent antibacterial activity against B. subtilis and K. pneumoniae and also complex 2 has shown good antifungal activity against the micro organisms. The antioxidant activity analysis revealed that the complex 3 showed significant activity with IC50 values 7.24 ± 0.09 µM. Moreover, the in vitro antiproliferative activity results suggested that complex 3 exhibited high activity against HeLa cell line compared with the standard with the IC50 value 16.52 ± 1.08 µM. The docking results correlate well. |
| Databáze: | OpenAIRE |
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