The Fungal Gut Microbiome Exhibits Reduced Diversity and Increased Relative Abundance of Ascomycota in Severe COVID-19 Illness and Distinct Interconnected Communities in SARS-CoV-2 Positive Patients
| Autor: | Johanna Reinold, Farnoush Farahpour, Ann-Kathrin Schoerding, Christian Fehring, Sebastian Dolff, Margarethe Konik, Johannes Korth, Lukas van Baal, Jan Buer, Oliver Witzke, Astrid M. Westendorf, Jan Kehrmann |
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| Rok vydání: | 2022 |
| Předmět: |
Medizinische Fakultät » Universitätsklinikum Essen » Institut für Medizinische Mikrobiologie
Microbiology (medical) Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Endokrinologie Diabetologie und Stoffwechsel Bacteria SARS-CoV-2 Immunology Medizin COVID-19 macromolecular substances Microbiology Gastrointestinal Microbiome mycobiome -- SARS-CoV-2 -- COVID-19 -- intestinal microbiota -- co-occurrence network -- severity Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Infektiologie Infectious Diseases Fakultät für Biologie » Bioinformatics and Computational Biophysics Ascomycota Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Nephrologie Dysbiosis Humans ddc:610 Mycobiome |
| Zdroj: | Frontiers in Cellular and Infection Microbiology. 12 |
| ISSN: | 2235-2988 |
| DOI: | 10.3389/fcimb.2022.848650 |
| Popis: | Clinical and experimental studies indicate that the bacterial and fungal gut microbiota modulates immune responses in distant organs including the lungs. Immune dysregulation is associated with severe SARS-CoV-2 infection, and several groups have observed gut bacterial dysbiosis in SARS-CoV-2 infected patients, while the fungal gut microbiota remains poorly defined in these patients. We analyzed the fungal gut microbiome from rectal swabs taken prior to anti-infective treatment in 30 SARS-CoV-2 positive (21 non-severe COVID-19 and 9 developing severe/critical COVID-19 patients) and 23 SARS-CoV-2 negative patients by ITS2-sequencing. Pronounced but distinct interconnected fungal communities distinguished SARS-CoV-2 positive and negative patients. Fungal gut microbiota in severe/critical COVID-19 illness was characterized by a reduced diversity, richness and evenness and by an increase of the relative abundance of the Ascomycota phylum compared with non-severe COVID-19 illness. A dominance of a single fungal species with a relative abundance of >75% was a frequent feature in severe/critical COVID-19. The dominating fungal species were highly variable between patients even within the groups. Several fungal taxa were depleted in patients with severe/critical COVID-19.The distinct compositional changes of the fungal gut microbiome in SARS-CoV-2 infection, especially in severe COVID-19 illness, illuminate the necessity of a broader approach to investigate whether the differences in the fungal gut microbiome are consequences of SARS-CoV-2 infection or a predisposing factor for critical illness. |
| Databáze: | OpenAIRE |
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