Sex-specific vagal and spinal modulation of swallow and its coordination with breathing
Autor: | Alyssa Huff, Dena R. Howland, Kimberly E. Iceman, Teresa Pitts, Mitchell D. Reed |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Critical Care and Emergency Medicine Lidocaine Physiology medicine.medical_treatment Respiratory System Vagotomy Nervous System Procedures Rats Sprague-Dawley 0302 clinical medicine Thoracic Diaphragm Medicine and Health Sciences Lung volumes Sex Characteristics Multidisciplinary Ingestion Respiration digestive oral and skin physiology Vagus Nerve Thorax Trachea Bioassays and Physiological Analysis Spinal Cord Breathing Anesthesia Excitatory postsynaptic potential Pleurae Medicine Female Anatomy Muscle Electrophysiology medicine.drug Research Article Resuscitation Science Sensory system Surgical and Invasive Medical Procedures Inhibitory postsynaptic potential Research and Analysis Methods 03 medical and health sciences medicine otorhinolaryngologic diseases Animals Balance (ability) business.industry Electromyography Electrophysiological Techniques Biology and Life Sciences Swallowing Deglutition Rats 030228 respiratory system business Physiological Processes 030217 neurology & neurosurgery |
Zdroj: | PLoS ONE, Vol 15, Iss 6, p e0234194 (2020) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Swallow-breathing coordination is influenced by changes in lung volume, which is modulated by feedback from both vagal and spinal sensory afferents. The purpose of this study was to manipulate feedback from these afferents, with and without a simultaneous mechanical challenge (chest compression), in order to assess the influence of each sensory pathway on swallow in rats. We hypothesized that manipulation of afferent feedback would shift the occurrence of swallow toward the inspiratory phase of breathing. Afferent feedback was perturbed by lidocaine nebulization, extra-thoracic vagotomy, or lidocaine administration to the pleural space in sodium pentobarbital anesthetized rats (N = 43). These different afferent perturbations were performed both in control conditions (no chest compression), and with chest compression. Manipulating pulmonary stretch receptor-mediated volume feedback in male animals decreased swallow occurrence. Female rats appear to rely more on spinal afferent feedback, as swallow occurrence shifted to late expiration with chest compression and vagotomy or lidocaine injections. Results suggest that sex-specific mechanisms modulate swallow-breathing coordination, and that vagal feedback is inhibitory to swallow-related muscles, while spinal feedback from pleural afferents has excitatory effects. This study supports the theory that a balance of vagal and spinal afferent feedback is necessary to maintain an optimal swallow pattern and swallow-breathing coordination. |
Databáze: | OpenAIRE |
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