Sex-specific vagal and spinal modulation of swallow and its coordination with breathing

Autor: Alyssa Huff, Dena R. Howland, Kimberly E. Iceman, Teresa Pitts, Mitchell D. Reed
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Critical Care and Emergency Medicine
Lidocaine
Physiology
medicine.medical_treatment
Respiratory System
Vagotomy
Nervous System Procedures
Rats
Sprague-Dawley
0302 clinical medicine
Thoracic Diaphragm
Medicine and Health Sciences
Lung volumes
Sex Characteristics
Multidisciplinary
Ingestion
Respiration
digestive
oral
and skin physiology
Vagus Nerve
Thorax
Trachea
Bioassays and Physiological Analysis
Spinal Cord
Breathing
Anesthesia
Excitatory postsynaptic potential
Pleurae
Medicine
Female
Anatomy
Muscle Electrophysiology
medicine.drug
Research Article
Resuscitation
Science
Sensory system
Surgical and Invasive Medical Procedures
Inhibitory postsynaptic potential
Research and Analysis Methods
03 medical and health sciences
medicine
otorhinolaryngologic diseases
Animals
Balance (ability)
business.industry
Electromyography
Electrophysiological Techniques
Biology and Life Sciences
Swallowing
Deglutition
Rats
030228 respiratory system
business
Physiological Processes
030217 neurology & neurosurgery
Zdroj: PLoS ONE, Vol 15, Iss 6, p e0234194 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: Swallow-breathing coordination is influenced by changes in lung volume, which is modulated by feedback from both vagal and spinal sensory afferents. The purpose of this study was to manipulate feedback from these afferents, with and without a simultaneous mechanical challenge (chest compression), in order to assess the influence of each sensory pathway on swallow in rats. We hypothesized that manipulation of afferent feedback would shift the occurrence of swallow toward the inspiratory phase of breathing. Afferent feedback was perturbed by lidocaine nebulization, extra-thoracic vagotomy, or lidocaine administration to the pleural space in sodium pentobarbital anesthetized rats (N = 43). These different afferent perturbations were performed both in control conditions (no chest compression), and with chest compression. Manipulating pulmonary stretch receptor-mediated volume feedback in male animals decreased swallow occurrence. Female rats appear to rely more on spinal afferent feedback, as swallow occurrence shifted to late expiration with chest compression and vagotomy or lidocaine injections. Results suggest that sex-specific mechanisms modulate swallow-breathing coordination, and that vagal feedback is inhibitory to swallow-related muscles, while spinal feedback from pleural afferents has excitatory effects. This study supports the theory that a balance of vagal and spinal afferent feedback is necessary to maintain an optimal swallow pattern and swallow-breathing coordination.
Databáze: OpenAIRE
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