Altered Global Signal Topography in Schizophrenia
| Autor: | Matthew F. Glasser, John D. Murray, John H. Krystal, Charlie Schleifer, Godfrey D. Pearlson, Genevieve Yang, Grega Repovs, Alan Anticevic |
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| Předmět: |
Adult
Male Rest Cognitive Neuroscience Sensory system Biology 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Neural Pathways medicine Humans Sensory cortex Default mode network Brain Mapping medicine.diagnostic_test Resting state fMRI Healthy subjects Brain Original Articles medicine.disease Magnetic Resonance Imaging 030227 psychiatry Oxygen medicine.anatomical_structure Schizophrenia Cerebrovascular Circulation Female Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery Neuropsychiatric disease |
| Zdroj: | ResearcherID |
| Popis: | Schizophrenia (SCZ) is a disabling neuropsychiatric disease associated with disruptions across distributed neural systems. Resting-state functional magnetic resonance imaging has identified extensive abnormalities in the blood-oxygen level-dependent signal in SCZ patients, including alterations in the average signal over the brain-i.e. the "global" signal (GS). It remains unknown, however, if these "global" alterations occur pervasively or follow a spatially preferential pattern. This study presents the first network-by-network quantification of GS topography in healthy subjects and SCZ patients. We observed a nonuniform GS contribution in healthy comparison subjects, whereby sensory areas exhibited the largest GS component. In SCZ patients, we identified preferential GS representation increases across association regions, while sensory regions showed preferential reductions. GS representation in sensory versus association cortices was strongly anti-correlated in healthy subjects. This anti-correlated relationship was markedly reduced in SCZ. Such shifts in GS topography may underlie profound alterations in neural information flow in SCZ, informing development of pharmacotherapies. |
| Databáze: | OpenAIRE |
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