In vitro immuno-stimulatory and anticancer activities of Oroxylum indicum (L.) Kurz.: An evidence for substitution of aerial parts for conservation
| Autor: | Uddagiri Venkanna Babu, Deeksha Rai, H.N. Aswatha Ram, L.M. Sharath Kumar, R. Kannan, K. Neeraj Patel |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Leaves
Population Biology chemistry.chemical_compound Drug Discovery Bioassay Original Research Article Chrysin Oroxylum indicum (L.) Kurz Miscellaneous systems and treatments education Medicinal plants education.field_of_study Traditional medicine RZ409.7-999 food and beverages biology.organism_classification Roots Oroxylum indicum In vitro Complementary and alternative medicine chemistry visual_art Stems visual_art.visual_art_medium Oroxylin A Bark |
| Zdroj: | Journal of Ayurveda and Integrative Medicine Journal of Ayurveda and Integrative Medicine, Vol 13, Iss 2, Pp 100523-(2022) |
| ISSN: | 0975-9476 |
| DOI: | 10.1016/j.jaim.2021.09.001 |
| Popis: | Background In Ayurveda, “Dashamoolarishta” is one of the important composite herbal formulations. Mainly, the root and root bark of Oroxylum indicum are used as one of the ingredients in its preparation. This leads to over exploitation of medicinal plants owing, to excessive demand due to population expansion and its perceived importance in traditional herbal remedies. Objective For the conservation of biodiversity, the present investigation had an objective to prepare the extracts of different parts of O. indicum plant and to, compare the chemo-profiles as well as to study the biological activities of the prepared extracts. Materials and methods Hydro-alcoholic (HA) and aqueous (Aq) extracts of various plant parts were prepared and chemical investigation was done with the help of (LC-MS/MS). Further, in vitro biological activities such as immuno-stimulation (IS) using a cytokine bioassay in RAW264.7 and in vitro anticancer in TNF-α ELISA in THP-1 cells were studied. Results The mass spectral profile of the plant revealed the presence of markers such as oroxylin A and chrysin in HA and Aq extracts of stem, leaf, bark and root. Cytokine release and TNF-α secretion was observed in both hydro-alcoholic and aqueous extracts. Conclusion Based on the results from the present study, it can be concluded that it is possible to replace the roots and the bark of O. indicum with the stem of young plants and leaves. It paves a way for the conserving the medicinal plants without uprooting and extinguishing the whole plant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|