The Dorsal Striatum Sets the Sensitivity to Effort
| Autor: | Bastien Berret, Corane Karoutchi, Maria-Teresa Jurado-Parras, Jordane Louis, Stefania Sarno, David Robbe, Mostafa Safaie |
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| Rok vydání: | 2020 |
| Předmět: |
Dorsum
0303 health sciences 050208 finance Computer science 05 social sciences Motor control Striatum Kinematics Expression (mathematics) Procedural memory 03 medical and health sciences 0302 clinical medicine 0502 economics and business Sensitivity (control systems) 050207 economics Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | SSRN Electronic Journal. |
| ISSN: | 1556-5068 |
| Popis: | The dorsal striatum (dS) has been implicated in storing and retrieving procedural memories and controlling movement kinematics (e.g., speed). Since procedural memories are expressed through movements, the exact nature of the dS function has proven difficult to delineate. Here we challenged rats in complementary tasks designed to alleviate this performance confound. Surprisingly, dS lesions spared task-specific procedural memories but altered the kinematics of their expression in motor routines. Further behavioral analyses combined with simulations in the optimal control framework indicated that these alterations reflected an increased sensitivity to effort with preserved reward-seeking and ability to modulate movement speed. By setting the sensitivity to effort, the dS contributes to the optimization of the energy invested into voluntary movements. Such an elementary function of the dS might explain its implication in both procedural decisions and the control of movement speed. |
| Databáze: | OpenAIRE |
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